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Cat. No.: HY-19863A

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F-15599 tosylate

(Synonyms: NLX-101 tosylate)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

F-15599 tosylate is a highly selective G-protein biased 5-HT1A receptor agonist, with K_i of 3.4 nM.

For research use only. We do not sell to patients.

CAS No.: 955112-72-8
Formula: C₂₆H₂₉ClF₂N₄O₄S
Molecular Weight:567.05

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

F-15599 tosylate Chemical Structure

CAS No.: 955112-72-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

F-15599 tosylate is a highly selective G-protein biased 5-HT1A receptor agonist, with K_i of 3.4 nM.

IC₅₀ & Target

5-HT_1A Receptor

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 955112-72-8
Molecular Weight 567.05
Formula C₂₆H₂₉ClF₂N₄O₄S
SMILES

O=C(N1CCC(CNCC2=NC=C(C)C=N2)(CC1)F)C3=CC=C(C(Cl)=C3)F.O=S(O)(C4=CC=C(C)C=C4)=O
Synonyms

NLX-101 tosylate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Mol Pharmacol

G α Protein Signaling Bias at Serotonin 1A Receptor. [Abstract]

2023 Nov;104(5):230-238. PMID: 37567783
Pharmacol Biochem Behav

Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice. [Abstract]

2024 May:238:173749. PMID: 38462045

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Meadows SM, et al. Characterizing the differential roles of striatal 5-HT1A auto- and hetero-receptors in the reduction of l-DOPA-induced dyskinesia. Exp Neurol. 2017 Jun;292:168-178. [Content Brief]

[2]. de Boer SF, et al. Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT?A receptor agonists F15599 and F13714 in male WTG rats. Psychopharmacology (Berl). 2016 Mar;233(6):937-47. [Content Brief]

[3]. Lladó-Pelfort L, et al. Preferential in vivo action of F15599, a novel 5-HT(1A) receptor agonist, at postsynaptic 5-HT(1A) receptors. Br J Pharmacol. 2010 Aug;160(8):1929-40. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

F-15599 tosylate

2 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Purity & Documentation
References

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F-15599 tosylate

Publications Citing Use of MedChemExpress (MCE) F-15599 tosylate

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

F-15599 tosylate Related Classifications

HY-19863A Related Classifications