FGFR4-IN-17
FGFR4-IN-17 (Compound (S)-23) is a piperazinyl diflurindan derivative containing pyridinyl. FGFR4-IN-17 is a FGFR inhibitor with IC50 values of 24.2, 16.1, 78.0, and 68.0 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FGFR4-IN-17 has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 3011805-61-8
- Formula: C29H27F3N4O2
- Molecular Weight:520.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KG-1a | GI50 |
10.4 nM
Compound: (S)-23
|
Growth inhibition against human KG-1a cells incubated for 72 to 96 hrs by MTT assay
Growth inhibition against human KG-1a cells incubated for 72 to 96 hrs by MTT assay
|
[PMID: 38294952] |
| KMS-11 | GI50 |
195 nM
Compound: (S)-23
|
Growth inhibition against human KMS-11 cells incubated for 72 to 96 hrs by MTT assay
Growth inhibition against human KMS-11 cells incubated for 72 to 96 hrs by MTT assay
|
[PMID: 38294952] |
| MDA-MB-453 | GI50 |
93 nM
Compound: (S)-23
|
Growth inhibition against human MDA-MB-453 cells incubated for 72 to 96 hrs by MTT assay
Growth inhibition against human MDA-MB-453 cells incubated for 72 to 96 hrs by MTT assay
|
[PMID: 38294952] |
| MFE-296 | GI50 |
17 nM
Compound: (S)-23
|
Growth inhibition against human MFE-296 cells incubated for 72 to 96 hrs by MTT assay
Growth inhibition against human MFE-296 cells incubated for 72 to 96 hrs by MTT assay
|
[PMID: 38294952] |
| NCI-H716 | GI50 |
6.4 nM
Compound: (S)-23
|
Growth inhibition against human NCI-H716 cells incubated for 72 to 96 hrs by MTT assay
Growth inhibition against human NCI-H716 cells incubated for 72 to 96 hrs by MTT assay
|
[PMID: 38294952] |
Chemical Information
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CAS No. 3011805-61-8
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Molecular Weight 520.55
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Formula C29H27F3N4O2
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SMILES
FC1(C2=CC(NC(C3=CC(C#CC4=CN=CC(OC)=C4)=C(C=C3)F)=O)=CC=C2[C@@H](N5CCN(CC5)C)C1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)