ABC294735
ABC294735 is an orally active SK1/SK2 inhibitor. Combination of ABC294735 with Sorafenib (HY-10201) reduces pERK. ABC294735 exhibits anticancer activity against pancreatic adenocarcinoma and renal cell carcinoma. ABC294735 can be used in research related to pancreatic adenocarcinoma and renal cell carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 917236-13-6
- Formula: C25H28ClNO3
- Molecular Weight:425.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SphK1 |
SphK2 |
ABC294735 (48 h) inhibits proliferation of human kidney carcinoma A-498 cells with an IC50 of 20 μM and human pancreatic adenocarcinoma Bxpc-3 cells with an IC50 of 40 μM after 48 hours of exposure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A-498; Bxpc-3
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Concentration:25 μM
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Incubation Time:48 h
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Result:Synergized with Sorafenib to reduce the levels of phosphorylated ERK1/2 (pERK).
Synergized with Gemcitabin to reduce the levels of phosphorylated ERK1/2 (pERK).
Did not show changes in total ERK1/2 protein.
ABC294735 (50 mg/kg; p.o.; daily Monday to Friday) delays pancreatic adenocarcinoma xenograft tumor growth without overt toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice[1]
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Dosage:50 mg/kg
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Administration:p.o.; daily Monday to Friday
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Result:Delayed tumor growth in the xenograft model.
Increased tumor growth inhibition when co-administered with sorafenib, though this decrease did not reach statistical significance.
Increased numbers of TUNEL-positive apoptotic cells in tumors when co-administered with sorafenib compared to single-agent treatment.
Reduced p-ERK levels in A-498 tumors when co-administered with sorafenib.
Caused no significant mouse weight loss or increased apoptotic cells in normal tissues (small intestine, liver).
Chemical Information
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CAS No. 917236-13-6
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Molecular Weight 425.95
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Formula C25H28ClNO3
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SMILES
O=C(NCCC1=CC=C(O)C(O)=C1)C23CC4CC(C2)CC(C5=CC=C(Cl)C=C5)(C4)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ABC294735 Related Classifications
HY-112385 Related Classifications
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- ABC294735
- 917236-13-6
- ABC 294735
- ABC-294735
- SphK
- PERK
- sphingosine kinase 2
- sphingosine-1-phosphate
- sphingosine kinase 1
- MAPK pathway
- kidney carcinoma
- pancreatic adenocarcinoma
- human pancreatic adenocarcinoma Bxpc-3 cells
- human kidney carcinoma A-498 cells
- apoptosis
- sphingosine phosphorylation
- Inhibitor
- inhibitor
- inhibit