AR7
Based on 15 publication(s) in Google Scholar
AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.38%
- No. CAS: 80306-38-3
- Fòrmula: C15H12ClNO
- Peso molecular:257.71
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) AR7
More- Signal Transduct Target Ther. 2025 Nov 3;10(1):360. [Abstract]
- Mol Cancer. 2025 Mar 17;24(1):82. [Abstract]
- Bone Res. 2025 Jun 12;13(1):62. [Abstract]
- Acta Pharm Sin B. 2026 Jul;16(7):4410-4425. [Abstract]
- Autophagy. 2025 Mar 20. [Abstract]
- Autophagy. 2025 Feb;21(2):352-373. [Abstract]
- Adv Sci (Weinh). 2025 Nov 21:e16015. [Abstract]
- Allergy. 2022 Feb;77(2):483-498. [Abstract]
- J Neuroinflammation. 2021 Dec 20;18(1):295. [Abstract]
- Diabetes. 2022 Dec 1;71(12):2764-2776. [Abstract]
- JCI Insight. 2026 Apr 23;11(11):e203575. [Abstract]
- Chem Biol Interact. 2024 Dec 4:111341. [Abstract]
- Int J Mol Sci. 2023 Sep 30;24(19):14786. [Abstract]
- Biochem Biophys Res Commun. 2025 Sep 1:777:152270. [Abstract]
- Biochem Biophys Res Commun. 2020 Jul 23;528(2):276-284. [Abstract]
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
10 μM
Compound: 11
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Cytotoxicity against human HepG2 cells in hypoxic condition after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells in hypoxic condition after 48 hrs by MTT assay
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[PMID: 19515559] |
Treatment with RARA antagonist, AR7 (20 μM; for 16 h), increased lysosomal activity in WT and LRRK2R1441G KI mutant MEFs[1].
AR7 (10, 20, 30 uM; 12, 24 hours) has no effect on macroautophagy in NIH 3T3 cells[2].
Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7 significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 80306-38-3
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Appearance Solid
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Peso molecular 257.71
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Fòrmula C15H12ClNO
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Color White to off-white
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SMILES
CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (15)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Microglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer's disease therapy. [Abstract]2025 Nov 3;10(1):360. PMID: 41184271 -
Mol Cancer
o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy. [Abstract]2025 Mar 17;24(1):82. PMID: 40098195
AR7 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 17;24(1):82. [Abstract]
AR7 (10-20 μM; 24 h) dose-dependently decreased HK2 and PKM2 protein expression levels in A549 and H1299 cells.
AR7 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 17;24(1):82. [Abstract]
AR7 (10-20 μM; 24 h) dose-dependently decreased ATG5 protein expression levels in A549 and H1299 cells.
AR7 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 17;24(1):82. [Abstract]
AR7 (20 μM; 24 h) reversed the increased of HK2 and PKM2 in A549 cells induced by circPLCE1 overexpression.
AR7 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 17;24(1):82. [Abstract]
AR7 (20 μM; 24 h) reversed the decrease in CMA activity induced by circPLCE1 overexpression, leading to a reduction in ATG5 expression in A549 cells.
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Bone Res
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration. [Abstract]2025 Jun 12;13(1):62. PMID: 40506462
AR7 purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jun 12;13(1):62. [Abstract]
AR7 (50 μM) significantly decreased DYRK1A levels in NPC.
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Acta Pharm Sin B
Insights into SARS-CoV-2 replication control via targeting the host hijacking function of NSP12. [Abstract]2026 Jul;16(7):4410-4425. PMID: 42453420 -
Autophagy
Chaperone-mediated autophagy degrades SERPINA1E342K/α1-antitrypsin Z variant and alleviates cell stress. [Abstract]2025 Mar 20. PMID: 40114294 -
Autophagy
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration. [Abstract]2025 Feb;21(2):352-373. PMID: 39212196 -
Adv Sci (Weinh)
Acetylation Regulates ACSL4 Degradation Through Chaperone-Mediated Autophagy to Alleviate Intervertebral Disc Degeneration. [Abstract]2025 Nov 21:e16015. PMID: 41270209 -
Allergy
The bile acid-activated retinoic acid response in dendritic cells is involved in food allergen sensitization. [Abstract]2022 Feb;77(2):483-498. PMID: 34365653 -
J Neuroinflammation
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. [Abstract]2021 Dec 20;18(1):295. PMID: 34930303 -
Diabetes
Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative Stress Under Hyperglycemic Conditions. [Abstract]2022 Dec 1;71(12):2764-2776. PMID: 36170669 -
JCI Insight
GLS1 governs vascular smooth muscle cell phenotypic switching and aortic dissection via glutamate metabolism. [Abstract]2026 Apr 23;11(11):e203575. PMID: 42024443 -
Chem Biol Interact
Deferoxamine-induced neurotoxicity: Role of chaperone-mediated autophagy dysfunction in neuronal apoptosis in the hippocampus. [Abstract]2024 Dec 4:111341. PMID: 39643152 -
Int J Mol Sci
PIP5Kγ Mediates PI(4,5)P2/Merlin/LATS1 Signaling Activation and Interplays with Hsc70 in Hippo-YAP Pathway Regulation. [Abstract]2023 Sep 30;24(19):14786. PMID: 37834234 -
Biochem Biophys Res Commun
Rapid proteasomal degradation of the stress response protein REDD2 is mediated by the E3 ligase HUWE1. [Abstract]2025 Sep 1:777:152270. PMID: 40609208 -
Biochem Biophys Res Commun
2020 Jul 23;528(2):276-284. PMID: 32475642
AR7 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2020 Jul 23;528(2):276-284. [Abstract]
After treated with 1 μM AR7 for 3 days, the protein expression of CD11b, CEBPβ is detected by immunobloting and quantified.
Solvente y solubilidad
DMSO : 25 mg/mL (97.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Philip Wing-Lok Ho, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2020 Feb;16(2):347-370. [Content Brief]
[2]. Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184(10):2696-2714.e25. [Content Brief]
[3]. Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8803 mL | 19.4017 mL | 38.8033 mL | 97.0083 mL |
| 5 mM | 0.7761 mL | 3.8803 mL | 7.7607 mL | 19.4017 mL | |
| 10 mM | 0.3880 mL | 1.9402 mL | 3.8803 mL | 9.7008 mL | |
| 15 mM | 0.2587 mL | 1.2934 mL | 2.5869 mL | 6.4672 mL | |
| 20 mM | 0.1940 mL | 0.9701 mL | 1.9402 mL | 4.8504 mL | |
| 25 mM | 0.1552 mL | 0.7761 mL | 1.5521 mL | 3.8803 mL | |
| 30 mM | 0.1293 mL | 0.6467 mL | 1.2934 mL | 3.2336 mL | |
| 40 mM | 0.0970 mL | 0.4850 mL | 0.9701 mL | 2.4252 mL | |
| 50 mM | 0.0776 mL | 0.3880 mL | 0.7761 mL | 1.9402 mL | |
| 60 mM | 0.0647 mL | 0.3234 mL | 0.6467 mL | 1.6168 mL | |
| 80 mM | 0.0485 mL | 0.2425 mL | 0.4850 mL | 1.2126 mL |
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