BAY-293
Based on 2 publication(s) in Google Scholar
BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.97%
- No. CAS: 2244904-70-7
- Fòrmula: C25H28N4O2S
- Peso molecular:448.58
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Publications Citing Use of MedChemExpress (MCE) BAY-293
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Actividad biológica
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KRAS-SOS1 21 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-1 | IC50 |
3190 nM
Compound: Chemical Probe: Compound 23, BAY-293
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Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 30683722] |
| K562 | IC50 |
0.23 nM
Compound: BAY-293
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Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation
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[PMID: 37011767] |
| K562 | IC50 |
1090 nM
Compound: Chemical Probe: Compound 23, BAY-293
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Antiproliferative activity against human K562 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 30683722] |
| MOLM-13 | IC50 |
995 nM
Compound: Chemical Probe: Compound 23, BAY-293
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Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 30683722] |
| NCI-H358 | IC50 |
3480 nM
Compound: Chemical Probe: Compound 23, BAY-293
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Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 30683722] |
BAY-293 inhibits the activation of RAS in HeLa cells, with IC50 values in the submicromolar range[1].
BAY-293 (595 nM-3580 nM; 72 hours) shows efficient antiproliferative activity against wild-type KRAS cell lines (K-562, MOLM-13) and cell lines with KRASG12C mutation (NCI-H358, Calu-1)[1].
BAY-293 efficiently inhibits pERK levels in K-562 cells after incubation for 60 min without affecting total protein levels of ERK[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K-562, MOLM-13, H358 and Calu-1 cell lines
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Concentration:595-3580 nM
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Incubation Time:72 hours
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Result:IC50s of 1,090±170 nM, 995±400 nM, 3,480±100 nM and 3,190±50 nM for K-562, MOLM-13, H358 and Calu-1 cells, respectively.
Chemical Information
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No. CAS 2244904-70-7
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Appearance Solid
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Peso molecular 448.58
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Fòrmula C25H28N4O2S
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Color White to light yellow
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SMILES
COC1=C(OC)C=C(N=C(C)N=C2N[C@H](C)C3=CC(C4=C(CNC)C=CC=C4)=CS3)C2=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation. [Abstract]2022 Sep 12;7(1):317. PMID: 36097006 -
Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175
Solvente y solubilidad
DMSO : 100 mg/mL (222.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2293 mL | 11.1463 mL | 22.2926 mL | 55.7314 mL |
| 5 mM | 0.4459 mL | 2.2293 mL | 4.4585 mL | 11.1463 mL | |
| 10 mM | 0.2229 mL | 1.1146 mL | 2.2293 mL | 5.5731 mL | |
| 15 mM | 0.1486 mL | 0.7431 mL | 1.4862 mL | 3.7154 mL | |
| 20 mM | 0.1115 mL | 0.5573 mL | 1.1146 mL | 2.7866 mL | |
| 25 mM | 0.0892 mL | 0.4459 mL | 0.8917 mL | 2.2293 mL | |
| 30 mM | 0.0743 mL | 0.3715 mL | 0.7431 mL | 1.8577 mL | |
| 40 mM | 0.0557 mL | 0.2787 mL | 0.5573 mL | 1.3933 mL | |
| 50 mM | 0.0446 mL | 0.2229 mL | 0.4459 mL | 1.1146 mL | |
| 60 mM | 0.0372 mL | 0.1858 mL | 0.3715 mL | 0.9289 mL | |
| 80 mM | 0.0279 mL | 0.1393 mL | 0.2787 mL | 0.6966 mL | |
| 100 mM | 0.0223 mL | 0.1115 mL | 0.2229 mL | 0.5573 mL |
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