EPAC 5376753
Based on 1 Customer Validation
EPAC 5376753, a 2-Thiobarbituric acid (HY-77962) derivative, is a selective and allosteric Epac inhibitor. EPAC 5376753 inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. EPAC 5376753 does not inhibit PKA and adenylyl cyclases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.10%
- No. CAS: 302826-61-5
- Fòrmula: C15H8Cl2N2O3S
- Peso molecular:367.21
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
IC50: 4 µM (Epac)[1]
EPAC 5376753 (1-100 μM; 48 h) above 50 μM will significantly inhibit cell activity, and below 50 μM will have no effect on cell activity[1].
Epac is a key mediator of cAMP signaling. EPAC 5376753 selectively inhibits Epac-mediated migration in fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Swiss 3T3 cells
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Concentration:1 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM
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Incubation Time:48 h
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Result:<50 μM of compound did not significantly decrease viability.
>50 μM significantly inhibited cell activity.
Chemical Information
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No. CAS 302826-61-5
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Appearance Solid
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Peso molecular 367.21
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Fòrmula C15H8Cl2N2O3S
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Color Orange to red
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SMILES
O=C(/C(C(N1)=O)=C/C2=CC=C(C3=CC=C(Cl)C=C3Cl)O2)NC1=S
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EPAC 5376753 Related Classifications
HY-111446 Related Classifications
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