HJC0350
Based on 2 publication(s) in Google Scholar
HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.11%
- No. CAS: 885434-70-8
- Fòrmula: C15H19NO2S
- Peso molecular:277.38
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Publications Citing Use of MedChemExpress (MCE) HJC0350
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Actividad biológica
IC50: 0.3 µM (EPAC2)[1]
HJC0350 has an apparent IC50 value of 0.3 μM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 μM HJC0350 fully blocks the 007-AM induced decrease of FRET[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 885434-70-8
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Appearance Solid
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Peso molecular 277.38
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Fòrmula C15H19NO2S
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Color White to off-white
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SMILES
O=S(N1C(C)=CC(C)=C1)(C2=C(C)C=C(C)C=C2C)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
AWRK6, a Novel GLP-1 Receptor Agonist, Attenuates Diabetes by Stimulating Insulin Secretion. [Abstract]2018 Oct 7;19(10). pii: E3053. PMID: 30301245 -
Stem Cells
β-Arrestin 2 and Epac2 Cooperatively Mediate DRD1-Stimulated Proliferation of Human Neural Stem Cells and Growth of Human Cerebral Organoids. [Abstract]2022 Sep 26;40(9):857-869. PMID: 35772103
Solvente y solubilidad
DMSO : 33.33 mg/mL (120.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Portuguese - PT (701 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6052 mL | 18.0258 mL | 36.0516 mL | 90.1291 mL |
| 5 mM | 0.7210 mL | 3.6052 mL | 7.2103 mL | 18.0258 mL | |
| 10 mM | 0.3605 mL | 1.8026 mL | 3.6052 mL | 9.0129 mL | |
| 15 mM | 0.2403 mL | 1.2017 mL | 2.4034 mL | 6.0086 mL | |
| 20 mM | 0.1803 mL | 0.9013 mL | 1.8026 mL | 4.5065 mL | |
| 25 mM | 0.1442 mL | 0.7210 mL | 1.4421 mL | 3.6052 mL | |
| 30 mM | 0.1202 mL | 0.6009 mL | 1.2017 mL | 3.0043 mL | |
| 40 mM | 0.0901 mL | 0.4506 mL | 0.9013 mL | 2.2532 mL | |
| 50 mM | 0.0721 mL | 0.3605 mL | 0.7210 mL | 1.8026 mL | |
| 60 mM | 0.0601 mL | 0.3004 mL | 0.6009 mL | 1.5022 mL | |
| 80 mM | 0.0451 mL | 0.2253 mL | 0.4506 mL | 1.1266 mL | |
| 100 mM | 0.0361 mL | 0.1803 mL | 0.3605 mL | 0.9013 mL |
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