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Referencia número: HY-19217

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Thioflosulide

(Synonyms: L-745337)

Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC₅₀ of 2.3 nM, and shows anti-inflammatory activity.

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No. CAS: 158205-05-1
Fòrmula: C₁₆H₁₃F₂NO₃S₂
Peso molecular:369.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Thioflosulide Chemical Structure

No. CAS: 158205-05-1

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC₅₀ of 2.3 nM, and shows anti-inflammatory activity.

IC₅₀ & Target^[3]

COX-2

2.3 nM (IC₅₀)

Ver todos los productos específicos de isoformas COX :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.029 μM Compound: L-745337	Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cells Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cells	[PMID: 10021918]
U-937	IC₅₀	>50 μM Compound: 20	Inhibition of Prostaglandin G/H synthase 1 in human U937 cells Inhibition of Prostaglandin G/H synthase 1 in human U937 cells	[PMID: 8523403]

In Vivo

In a rat model of postoperative pain, Thioflosulide (L-745337) (40-80 μg, intrathecal) coadministered with intrathecal morphine (0.5 nmol) increases the withdrawal thresholds in a dose-dependent manner. Adding 80 μg Thioflosulide (L-745337) to 1 nmol morphine produces an antiallodynic effect greater than that of morphine at twice the dose. Thioflosulide (L-745337) (0-30 mg/kg, s.c.) combined with intrathecal morphine results in the same antiallodynic response as morphine alone^[1]. Thioflosulide (L-745337) shows anti-inflammatory activity, with the effective-dose of 0.4 mg/kg, and the maximal anti-inflammation dose of 5 mg/kg in arthritic rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 158205-05-1
Peso molecular 369.41
Fòrmula C₁₆H₁₃F₂NO₃S₂
SMILES

CS(=O)(NC1=CC2=C(C(CC2)=O)C=C1SC3=CC=C(F)C=C3F)=O
Synonyms

L-745337
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kroin JS, et al. Cyclooxygenase-2 inhibition potentiates morphine antinociception at the spinal level in a postoperative pain model. Reg Anesth Pain Med. 2002 Sep-Oct;27(5):451-5. [Content Brief]

[2]. Turull N, et al. Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats. Inflammation. 2000 Dec;24(6):533-45. [Content Brief]

[3]. Li CS, et al. Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives. J Med Chem. 1995 Dec 8;38(25):4897-905. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- In Vivo
Chemical Information
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Thioflosulide

Ver todos los productos específicos de isoformas COX

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Thioflosulide Related Classifications

HY-19217 Related Classifications