Thiazolyl Blue
(Synonyms: MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide)
192 Cited Publications
Revisión del cliente
Based on 192 publication(s) in Google Scholar
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.84%
- No. CAS: 298-93-1
- Fòrmula: C18H16BrN5S
- Peso molecular:414.32
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)
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Publications Citing Use of MedChemExpress (MCE) Thiazolyl Blue
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- Mol Cancer. 2025 Dec 11;24(1):306. [Abstract]
- Nat Cancer. 2025 May;6(5):768-785. [Abstract]
- Mater Today. 2026 Jun 19;98:103430.
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- Cell Mol Immunol. 2021 Mar;18(3):613-620. [Abstract]
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- Cell Death Differ. 2024 Jan;31(1):78-89. [Abstract]
- Acta Pharm Sin B. 2024 Jun;14(6):2685-2697. [Abstract]
- Adv Sci (Weinh). 2026 May 25:e75818. [Abstract]
- Carbohydr Polym. 2025 Nov 1:367:124023. [Abstract]
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- Acta Biomater. 2024 Sep 5:S1742-7061(24)00501-4. [Abstract]
- Cell Death Dis. 2023 Oct 11;14(10):671. [Abstract]
- Adv Healthc Mater. 2023 Jul;12(18):e2203342. [Abstract]
- Cell Death Dis. 2022 Dec 27;13(12):1075. [Abstract]
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Actividad biológica
Descripciòn
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis[1].
In Vitro
Guide (The following is the experimental plan we recommend. This plan serves only as a reference guide. The specific operations should be adjusted according to your actual needs.)
1. Preparation of MTT solution
Dissolve MTT in anhydrous DMSO to obtain a 5 mg/mL solution.
2. Cell proliferation assay (96-well plate)
2.1 Cell inoculation: Prepare single cells and prepare a suspension with 10% FBS culture medium. Inoculate them into a 96-well plate, with 1000-10,000 cells per well, and each well volume is 100 μL.
2.2 Cell culture: At 37°C, with 5% CO2, incubate for 24-72 hours.
2.3 Add 10 μL of MTT to each well, incubate for 4 hours, discard the supernatant, and the cells need to be centrifuged first.
2.4 Add 100 μL of DMSO, shake for 10 minutes to completely dissolve the crystals.
2.5 Use an absorbance plate reader to monitor the increase in absorbance at OD = 562 nm.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 298-93-1
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Appearance Solid
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Peso molecular 414.32
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Fòrmula C18H16BrN5S
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Color Light yellow to yellow
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SMILES
CC1=C(C)N=C(N2N=C(C3=CC=CC=C3)N=[N+]2C4=CC=CC=C4)S1.[Br-]
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Synonyms
MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)
Publications (192)
All
Journal Impact Factor
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Journal Impact Factor
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Most Recent
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Nat Biotechnol
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition. [Abstract]2024 May;42(5):731-744. PMID: 37537500 -
Mol Cancer
Transcriptional dynamics of CD8+ T-cell exhaustion in immune checkpoint inhibitor resistance at single-cell resolution. [Abstract]2025 Dec 11;24(1):306. PMID: 41382107 -
Nat Cancer
Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity. [Abstract]2025 May;6(5):768-785. PMID: 40108413 -
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Bioact Mater
Biodegradation behavior of micro-arc oxidation coating on magnesium alloy-from a protein perspective. [Abstract]2020 Mar 30;5(2):398-409. PMID: 32258829 -
Cell Mol Immunol
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. [Abstract]2021 Mar;18(3):613-620. PMID: 33110251 -
Nat Commun
2026 Jan 7;17(1):163. PMID: 41501012 -
Nat Commun
Asymmetric total synthesis of polycyclic xanthenes and discovery of a WalK activator active against MRSA. [Abstract]2024 Jul 13;15(1):5879. PMID: 38997253 -
Nat Commun
Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells. [Abstract]2022 Nov 10;13(1):6796. PMID: 36357388 -
Cell Death Differ
Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer. [Abstract]2024 Jan;31(1):78-89. PMID: 38007552 -
Acta Pharm Sin B
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer. [Abstract]2024 Jun;14(6):2685-2697. PMID: 38828153 -
Adv Sci (Weinh)
Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3-IFI6 Circuit in Breast Cancer. [Abstract]2026 May 25:e75818. PMID: 42183833 -
Carbohydr Polym
Hybrid bioink of methyacrylated starch with minimal methacrylated chitosan enables high-precision 3D printing for complex tissue scaffolds. [Abstract]2025 Nov 1:367:124023. PMID: 40817551 -
Carbohydr Polym
2022 Feb 1:277:118871. PMID: 34893276 -
Carbohydr Polym
2020 May 15;236:116058. PMID: 32172873 -
Small
2023 Apr;19(16):e2207194. PMID: 36634971 -
Redox Biol
Regulatory roles of NAMPT and NAD+ metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment. [Abstract]2024 Oct 26:78:103411. PMID: 39486360 -
J Hazard Mater
Formation of di-cysteine acrolein adduct decreases cytotoxicity of acrolein by ROS alleviation and apoptosis intervention. [Abstract]2020 Apr 5;387:121686. PMID: 31780296 -
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Biosens Bioelectron
A biosensor for D-2-hydroxyglutarate in frozen sections and intraoperative assessment of IDH mutation status. [Abstract]2024 Mar 1:247:115921. PMID: 38104390 -
Mater Today Bio
A bufalin and CRISPR/Cas9 ribonucleoprotein-loaded calcium lactate nanomedicine for pyroptosis/apoptosis and synergistic cancer immunotherapy. [Abstract]2025 Nov 7:35:102527. PMID: 41322154 -
Mater Today Bio
2022 Jul 19:16:100369. PMID: 35937571 -
Food Chem
Sturgeon (Acipenser schrenckii) spinal cord peptides: Antioxidative and acetylcholinesterase inhibitory efficacy and mechanisms. [Abstract]2024 Aug 12:461:140834. PMID: 39153375 -
Food Chem
Fish oil nano-emulsion kills macrophage: Ferroptosis triggered by catalase-catalysed superoxide eruption. [Abstract]2023 May 15:408:135249. PMID: 36566546 -
Food Chem
2021 Aug 1:352:129424. PMID: 33706136 -
Cell Death Dis
2026 Mar 19;17(1):323. PMID: 41856969 -
Acta Biomater
A tough Janus poly(vinyl alcohol)-based hydrogel for wound closure and anti postoperative adhesion. [Abstract]2024 Sep 5:S1742-7061(24)00501-4. PMID: 39243837 -
Cell Death Dis
PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target. [Abstract]2023 Oct 11;14(10):671. PMID: 37821451 -
Adv Healthc Mater
Mussel Foot Protein Inspired Tape-Type Adhesive with Water-Responsive, High Conformal, Tough, and On-Demand Detachable Adhesion to Wet Tissue. [Abstract]2023 Jul;12(18):e2203342. PMID: 36912388 -
Cell Death Dis
4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer. [Abstract]2022 Dec 27;13(12):1075. PMID: 36575176 -
Cell Commun Signal
Spinster homolog 2 (SPNS2) deficiency drives endothelial cell senescence and vascular aging via promoting pyruvate metabolism mediated mitochondrial dysfunction. [Abstract]2024 Oct 11;22(1):492. PMID: 39394598 -
Phytomedicine
Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition. [Abstract]2026 Jun:155:158147. PMID: 41966024 -
Phytomedicine
Usenamine a potentiates anti-CRC activity of sorafenib by inducing autophagy and inhibiting YAP pathway through targeting SOD2. [Abstract]2026 Jun:155:158086. PMID: 41861687 -
Phytomedicine
Pristimerin induces apoptosis and tumor inhibition of oral squamous cell carcinoma through activating ROS-dependent ER stress/Noxa pathway. [Abstract]2021 Nov:92:153723. PMID: 34482221 -
Phytomedicine
Effect of pristimerin on apoptosis through activation of ROS/ endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer. [Abstract]2021 Jan;80:153399. PMID: 33202325 -
Phytomedicine
Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK. [Abstract]2020 Nov;78:153306. PMID: 32854039 -
Food Chem X
Preparation, characterization, assembly, and stability of walnut peptide - zinc complexes and its ability to promote zinc transport in Caco-2 cells. [Abstract]2025 Sep 16:31:103046. PMID: 41036460 -
Free Radic Biol Med
Hinokitiol modulates Nrf2/HO-1 signaling, autophagy, and URAT1 in hyperuricemia and oxidative stress models of renal injury. [Abstract]2025 Jun 19:238:169-178. PMID: 40543854 -
ACS Appl Mater Interfaces
Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid. [Abstract]2023 Oct 4;15(39):45676-45688. PMID: 37733382 -
Drug Deliv
Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect. [Abstract]2020 Dec;27(1):983-995. PMID: 32611218 -
Mater Sci Eng C Mater Biol Appl
Carbon quantum dots embedded electrospun nanofibers for efficient antibacterial photodynamic inactivation. [Abstract]2020 Mar;108:110377. PMID: 31924045 -
Sci Total Environ
Glycidol induces necroptosis and inflammation through autophagy-necrosome pathway in renal cell and mice. [Abstract]2025 Mar 10:968:178852. PMID: 39965374 -
NPJ Precis Oncol
Methionine deprivation inhibits glioma proliferation and EMT via the TP53TG1/miR-96-5p/STK17B ceRNA pathway. [Abstract]2024 Nov 21;8(1):270. PMID: 39572759 -
Sci Total Environ
Multi-omics integration identifies ferroptosis involved in black phosphorus quantum dots-induced renal injury. [Abstract]2024 Jul 5:174532. PMID: 38972417 -
NPJ Sci Food
Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis. [Abstract]2025 Jul 31;9(1):163. PMID: 40744931 -
Biomed Pharmacother
Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress. [Abstract]2023 Oct:166:115327. PMID: 37619480 -
Biomed Pharmacother
Study on the potential of Sanghuangporus sanghuang and its components as COVID-19 spike protein receptor binding domain inhibitors. [Abstract]2022 Sep:153:113434. PMID: 36076488 -
Environ Pollut
DNA methylation-mediated alterations in Copper(I/II) redox equilibrium underlie lead-induced neurotoxicity. [Abstract]2026 Apr 1:394:127739. PMID: 41617047 -
Oncogene
TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC. [Abstract]2024 Feb;43(7):470-483. PMID: 38123820 -
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J Med Chem
SAR Study on Thiolato-Bridged Triosmium Carbonyl Clusters: Higher Reactivity Does Not Equal Higher Antiproliferative Activity. [Abstract]2024 Dec 12;67(23):20980-20985. PMID: 39585241 -
J Med Chem
5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2. [Abstract]2021 Sep 9;64(17):12537-12547. PMID: 34351142 -
J Med Chem
Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids. [Abstract]2018 Dec 13;61(23):10814-10833. PMID: 30433783 -
Antioxidants (Basel)
Main Bioactive Components and Their Biological Activities from Natural and Processed Rhizomes of Polygonum sibiricum. [Abstract]2022 Jul 17;11(7):1383. PMID: 35883874 -
NPJ Regen Med
Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration. [Abstract]2023 Oct 13;8(1):56. PMID: 37833374 -
Int J Pharm X
Formulation of multicomponent inclusion complex of cyclodextrin-amino acid with Chrysin: Physicochemical characterization, cell viability and apoptosis assessment in human primary glioblastoma cell line. [Abstract]2023 Sep 12:6:100211. PMID: 37736236 -
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Ecotoxicol Environ Saf
Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells. [Abstract]2025 Apr 3:295:118139. PMID: 40185034 -
Ecotoxicol Environ Saf
N6-methyladenosine facilitates arsenic-induced neoplastic phenotypes of human bronchial epithelial cells by promoting miR-106b-5p maturation. [Abstract]2024 Sep 15:283:116803. PMID: 39094460 -
Ecotoxicol Environ Saf
Alleviating 3-MCPD-induced male reproductive toxicity: Mechanistic insights and resveratrol intervention. [Abstract]2024 Feb:271:115978. PMID: 38262097 -
Eur J Med Chem
Discovery of a selenium-containing compound as a promising ferroptosis inducer attenuates prostate cancer progression. [Abstract]2025 Dec 5:299:118067. PMID: 40834498 -
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Eur J Med Chem
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer. [Abstract]2020 Nov 15;206:112677. PMID: 32823005 -
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Eur J Med Chem
A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway. [Abstract]2018 Aug 5:156:21-42. PMID: 30006166 -
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Biochem Pharmacol
Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. [Abstract]2024 May:223:116194. PMID: 38583812 -
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Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (60.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.88 mg/mL (2.12 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
View the Complete Stock Solution Preparation Table
Preparing Stock Solutions
View the Complete Stock Solution Preparation Table
Concentration
Solvent
Mass
1 mg
5 mg
10 mg
Concentration
Solvent
Mass
1 mM
2.4136 mL
12.0680 mL
24.1359 mL
5 mM
0.4827 mL
2.4136 mL
4.8272 mL
10 mM
0.2414 mL
1.2068 mL
2.4136 mL
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Calculadora de molaridad
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
=
×
×
Calculadora de dilución
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
Select Batch:
Pureza:
99.98%
Assay:
99.98%
ee.:
99.98%
-
Ficha de datos (278 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Berridge MV, et al. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-52. [Content Brief]
[2]. Berridge MV, et al. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.4136 mL | 12.0680 mL | 24.1359 mL | 60.3398 mL |
| DMSO | 5 mM | 0.4827 mL | 2.4136 mL | 4.8272 mL | 12.0680 mL |
| 10 mM | 0.2414 mL | 1.2068 mL | 2.4136 mL | 6.0340 mL | |
| 15 mM | 0.1609 mL | 0.8045 mL | 1.6091 mL | 4.0227 mL | |
| 20 mM | 0.1207 mL | 0.6034 mL | 1.2068 mL | 3.0170 mL | |
| 25 mM | 0.0965 mL | 0.4827 mL | 0.9654 mL | 2.4136 mL | |
| 30 mM | 0.0805 mL | 0.4023 mL | 0.8045 mL | 2.0113 mL | |
| 40 mM | 0.0603 mL | 0.3017 mL | 0.6034 mL | 1.5085 mL | |
| 50 mM | 0.0483 mL | 0.2414 mL | 0.4827 mL | 1.2068 mL | |
| 60 mM | 0.0402 mL | 0.2011 mL | 0.4023 mL | 1.0057 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thiazolyl Blue Related Classifications
HY-15924 Related Classifications
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