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Referencia número: HY-10216

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Refametinib (R enantiomer)

Name: Refametinib (R enantiomer)
Brand: MedChemExpress
SKU: HY-10216
Price: 70.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: BAY 869766 R enantiomer; RDEA119 R enantiomer)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC₅₀ of 2.0-15 nM.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 923032-38-6
Fòrmula: C₁₉H₂₀F₃IN₂O₅S
Peso molecular:572.34

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Refametinib (R enantiomer) Chemical Structure

No. CAS: 923032-38-6

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Actividad biológica

Descripciòn

Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC₅₀ of 2.0-15 nM.

IC₅₀ & Target

^[1]

MEK

2-15 nM (EC₅₀)

Ver todos los productos específicos de isoformas MEK :

In Vitro

Refametinib R enantiomer is the R enantiomer of Refametinib . Refametinib R enantiomer is an inhibitor of MEK and is useful in treatment of cancer and other hyperproliferative diseases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 923032-38-6
Peso molecular 572.34
Fòrmula C₁₉H₂₀F₃IN₂O₅S
SMILES

O=S(C1(C[C@H](CO)O)CC1)(NC(C(NC(C(F)=C2)=CC=C2I)=C3F)=C(OC)C=C3F)=O
Synonyms

BAY 869766 R enantiomer; RDEA119 R enantiomer
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Sci Adv

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS. [Abstract]

2019 Aug 14;5(8):eaav8463. PMID: 31453322

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Andreas Maderna, et al. N-(arylamino)-sulfonamide inhibitors of mek. WO 2007014011 A2.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Refametinib (R enantiomer)

1 Cited Publications

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureza y Documentación
Referencias

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Refametinib (R enantiomer)

Publications Citing Use of MedChemExpress (MCE) Refametinib (R enantiomer)

Ver todos los productos específicos de isoformas MEK