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Referencia número: HY-120687

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A68930

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 130465-45-1
Fòrmula: C₁₆H₁₇NO₃
Peso molecular:271.31

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

A68930 Chemical Structure

No. CAS: 130465-45-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Pureza y Documentación
Referencias
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Bioz

Actividad biológica

Descripciòn

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis^[1].

IC₅₀ & Target

D₁ Receptor

Ver todos los productos específicos de isoformas Dopamine Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
Pituitary gland cell	EC₅₀	10200 nM Compound: 22	Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary gland Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary gland	[PMID: 1652023]

In Vitro

A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein^[1].
A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression^[1].
A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

16HBE14o- or NCI-H292 cells
Concentration:

1 μM
Incubation Time:

5~60 minutes
Result:

Significantly increased phosphorylation of CREB.

RT-PCR^[1]

Cell Line:

NCI-H292 cells
Concentration:

1 μM
Incubation Time:

48 hours
Result:

Induced MUC5AC mRNA expression.

Immunofluorescence^[1]

Cell Line:

NCI-H292 cells
Concentration:

1 μM
Incubation Time:

48 hours
Result:

The mRNA data of MUC5AC, MUC5AC protein expression were increased.

Chemical Information

No. CAS 130465-45-1
Peso molecular 271.31
Fòrmula C₁₆H₁₇NO₃
SMILES

OC1=C2C[C@H](O[C@H](C2=CC=C1O)CN)C3=CC=CC=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

bioRxiv

Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection. [Abstract]

2026 Jan 6:2026.01.06.697936. PMID: 41542404

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

A68930

1 Cited Publications

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureza y Documentación
Referencias

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A68930

Publications Citing Use of MedChemExpress (MCE) A68930

Ver todos los productos específicos de isoformas Dopamine Receptor

Actividad biológica

Chemical Information

Publications (1)

Pureza y Documentación

Referencias

Calculators

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A68930 Related Classifications

HY-120687 Related Classifications