ABI793
ABI793 is a human IgG1 anti-human CD154 (CD40 ligand) monoclonal antibody. ABI793 inhibits immune response by blocking the CD154-CD40 (IC50 = 75 nM) signaling pathway. ABI793 effectively prevents kidney transplant rejection. ABI793 can be used for research on immunological rejection.
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
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Actividad biológica
Human
TNFSF5/CD40L/CD154
ABI793 inhibits CD154 and CD40 binding in a concentration dependent manner (IC50 = 75 nM)[1].
ABI793 (4 days) inhibits IL-4 stimulated B cell proliferation (IC50 = 73 nM)[1].
ABI793 (5 days) inhibits human mixed lymphocyte reaction (MLR) (IC50 = 320 ng/mL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ABI793 (20 mg/kg, i.v., on postoperative days 0, 1, 4, 11, 18, 28, 56, and 84) significantly prolongs the survival time of kidney transplantation in rhesus monkeys[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Renal allograft or autograft transplantation in Cynomolgus monkeys (3-8 kg)[1]
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Dosage:20 mg/kg
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Administration:Intravenous injection (i.v.) on postoperative days 0, 1, 4, 11, 18, 28, 56, and 84
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Result:Significantly prolonged the survival time of transplanted kidneys (median survival of 108 days).
Did not cause acute tubular necro-sis (ATN) or thrombocytopenia in autograft transplantation.
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Animal Model:Renal allograft transplantation in rhesus monkeys (4-6 years, 4-7 kg)[2]
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Dosage:20 mg/kg
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Administration:Intravenous injection (i.v.) on postoperative days 0, 1, 4, 11, 18, 28, 56, and 84
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Result:Significantly prolonged kidney transplant survival time (median survival of 149 days).
Did not cause abnormal liver and kidney function or hematological toxicity.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
N/A
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Schuler W, et al. Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation. Transplantation. 2004 Mar 15;77(5):717-26. [Content Brief]
[2]. Kanmaz T, et al. Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model. Transplantation. 2004 Mar 27;77(6):914-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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