Acetylcarnitine
Based on 1 Customer Validation
Acetylcarnitine is a CNS-penetrant endogenous metabolite. Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. Acetylcarnitine attenuates oxidative stress and neuroinflammation. Acetylcarnitine can be used for fatigue-associated diseases research. Acetylcarnitine can be used as a candidate diagnostic and prognostic biomarker of hepatocellular carcinoma.
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- Pureza: 98.0%
- No. CAS: 14992-62-2
- Fòrmula: C9H17NO4
- Peso molecular:203.24
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Almacenamiento:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
Acetylcarnitine (10 mM, 48 h) suppresses glucose-dependent labeling, particularly in ATP-citrate lyase (ACLY) KO cells[2].
Acetylcarnitine (10 mM, 24-96 h) rescues histone acetylation and cell proliferation in ACLY/ACSS2 double knockout (DKO) cells under lipid-depleted conditions[2].
Acetylcarnitine (10 mM, 24 h) boosts histone acetylation in ACLY KO cells in a carnitine acetyltransferase (CrAT)-independent manner, and increases total de novo lipogenesis (DNL) in ACLY KO CrAT KO cells, suggesting that acetylcarnitine can generate lipogenic acetyl-CoA without CrAT[2].
Acetylcarnitine (10 mM, 24-96 h) promotes p300/CBP-dependent protein acetylation, as its pro-proliferative effect in DKO cells is blocked by the p300/CBP inhibitor A-485 (HY-107455)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ACLY/ACSS2 DKO cells
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Concentration:10 mM
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Incubation Time:96 h
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Result:Rescued cell proliferation in DKO cells under lipid-depleted conditions.
The pro-proliferative effect of acetylcarnitine under lipid-depleted conditions was blocked by co-treatment with the p300/CBP inhibitor A-485.
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Cell Line:ACLY/ACSS2 DKO cells, ACLY KO cells, ACLY KO CrAT KO cells
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Concentration:10 mM
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Incubation Time:24 h
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Result:Rescued histone acetylation in ACLY/ACSS2 double knockout (DKO) cells under lipid-depleted conditions.
Promoted p300/CBP-dependent histone acetylation, specifically at H3K27.
Enhanced histone acetylation in ACLY KO cells in a CrAT-independent manner.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 14992-62-2
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Appearance Solid
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Peso molecular 203.24
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Fòrmula C9H17NO4
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Color White to off-white
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SMILES
C[N+](C)(C)CC(OC(C)=O)CC([O-])=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
H2O : 250 mg/mL (1230.07 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
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- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Helbing DL, et al. Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review. Eur Arch Psychiatry Clin Neurosci. 2024 Dec;274(8):1829-1845. [Content Brief]
[2]. Izzo LT, et al. Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. Sci Adv. 2023 May 3;9(18):eadf0115. [Content Brief]
[3]. Lu Y, et al. Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma. Cancer Res. 2016 May 15;76(10):2912-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9203 mL | 24.6015 mL | 49.2029 mL | 123.0073 mL |
| 5 mM | 0.9841 mL | 4.9203 mL | 9.8406 mL | 24.6015 mL | |
| 10 mM | 0.4920 mL | 2.4601 mL | 4.9203 mL | 12.3007 mL | |
| 15 mM | 0.3280 mL | 1.6401 mL | 3.2802 mL | 8.2005 mL | |
| 20 mM | 0.2460 mL | 1.2301 mL | 2.4601 mL | 6.1504 mL | |
| 25 mM | 0.1968 mL | 0.9841 mL | 1.9681 mL | 4.9203 mL | |
| 30 mM | 0.1640 mL | 0.8200 mL | 1.6401 mL | 4.1002 mL | |
| 40 mM | 0.1230 mL | 0.6150 mL | 1.2301 mL | 3.0752 mL | |
| 50 mM | 0.0984 mL | 0.4920 mL | 0.9841 mL | 2.4601 mL | |
| 60 mM | 0.0820 mL | 0.4100 mL | 0.8200 mL | 2.0501 mL | |
| 80 mM | 0.0615 mL | 0.3075 mL | 0.6150 mL | 1.5376 mL | |
| 100 mM | 0.0492 mL | 0.2460 mL | 0.4920 mL | 1.2301 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acetylcarnitine Related Classifications
HY-126358 Related Classifications
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