Astin C
Based on 1 Customer Validation
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers.
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- Pureza: 99.47%
- No. CAS: 148057-23-2
- Fòrmula: C25H33Cl2N5O6
- Peso molecular:570.47
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Astin C (10 μM; 6 h) significantly inhibits the expression of Ifnb mRNA induced by cGAS or STING in HEK293 cells[1].
Astin C (10 μM; 6 h) significantly impaires the interactions between STING and IRF3, as well as between STING and SCAP, and inhibits the aggregation of SCAP and IRF3 in HEK293T cells and MEFs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 treated cGAS or STING
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Concentration:10 μM
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Incubation Time:6 h
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Result:Inhibited the mRNA level of Ifnb.
In Vivo
Astin C (5.0 mg/kg; intraperitoneal injection; 5 days) achieves a tumor growth inhibition rate of 45% in male ICR mice inoculated with Sarcoma 180 ascites tumor[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Trex1-/- mice[1]
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Dosage:2 and 4 mg/kg
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Administration:Tail vein injection; once every 2 days; 7 days
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Result:Inhibited the expression of type I interferon and pro-inflammatory cytokines in Trex1-/- BMDMs.
Alleviated autoimmune inflammatory symptoms, decreased the abundance of sera autoantibodies, and reduced the percentage of activated CD8+ T cells in the spleen.
Chemical Information
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No. CAS 148057-23-2
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Appearance Solid
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Peso molecular 570.47
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Fòrmula C25H33Cl2N5O6
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Color Off-white to yellow
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Synonyms
Asterin
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Sequence
Cyclo({Abu}-Pro-{Abu}-Ser-{Oaa})
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Sequence Shortening
Cyclo({Abu}-P-{Abu}-S-{Oaa})
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (175.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Li S, et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Rep. 2018 Dec 18;25(12):3405-3421.e7. [Content Brief]
[2]. Antoine Vassaux, et al. Astin C Production by the Endophytic Fungus Cyanodermella asteris in Planktonic and Immobilized Culture Conditions. Biotechnol J. 2019 Aug;14(8):e1800624. [Content Brief]
[3]. Morita H, et al. Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus. Chem Pharm Bull (Tokyo). 1996 May;44(5):1026-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7529 mL | 8.7647 mL | 17.5294 mL | 43.8235 mL |
| 5 mM | 0.3506 mL | 1.7529 mL | 3.5059 mL | 8.7647 mL | |
| 10 mM | 0.1753 mL | 0.8765 mL | 1.7529 mL | 4.3824 mL | |
| 15 mM | 0.1169 mL | 0.5843 mL | 1.1686 mL | 2.9216 mL | |
| 20 mM | 0.0876 mL | 0.4382 mL | 0.8765 mL | 2.1912 mL | |
| 25 mM | 0.0701 mL | 0.3506 mL | 0.7012 mL | 1.7529 mL | |
| 30 mM | 0.0584 mL | 0.2922 mL | 0.5843 mL | 1.4608 mL | |
| 40 mM | 0.0438 mL | 0.2191 mL | 0.4382 mL | 1.0956 mL | |
| 50 mM | 0.0351 mL | 0.1753 mL | 0.3506 mL | 0.8765 mL | |
| 60 mM | 0.0292 mL | 0.1461 mL | 0.2922 mL | 0.7304 mL | |
| 80 mM | 0.0219 mL | 0.1096 mL | 0.2191 mL | 0.5478 mL | |
| 100 mM | 0.0175 mL | 0.0876 mL | 0.1753 mL | 0.4382 mL |
Astin C Related Classifications
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