AZD3409
AZD3409 is a prenyl inhibitor that exhibits inhibitory activity against both farnesyl transferase and geranylgeranyl transferase I. AZD3409 inhibits the growth of breast cancer cells, with IC50s of 220 nM (MDA-MB-468), 180 nM (MDA-MB-361), and 290 nM (SK-Br-3). AZD3409 significantly reduces the activation level of AKT in breast cancer cell lines. AZD3409 induces G0/G1 phase arrest in MDA-MB-468 cells, causes G2/M phase arrest in MDA-MB-361 cells. AZD3409 can be used for the study of breast cancer.
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- No. CAS: 345915-10-8
- Fòrmula: C34H41FN4O4S2
- Peso molecular:652.84
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
49 nM
Compound: 7
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In vivo inhibition of H-ras-transformed 3T3 fibroblasts in nude mouse tumor models
In vivo inhibition of H-ras-transformed 3T3 fibroblasts in nude mouse tumor models
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[PMID: 15055985] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 345915-10-8
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Peso molecular 652.84
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Fòrmula C34H41FN4O4S2
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SMILES
O=C(N[C@@H](CCSC)C(OC(C)C)=O)C1=CC(NC[C@H]2NC[C@H](C2)SC(C3=CN=CC=C3)=O)=CC=C1CCC4=CC=C(F)C=C4
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Synonyms
EBP-921
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZD3409 Related Classifications
HY-10062 Related Classifications
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