Barucainide
Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel). Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (Vmax) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD). Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias.
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- No. CAS: 79784-22-8
- Fòrmula: C22H30N2O2
- Peso molecular:354.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Actividad biológica
Chemical Information
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No. CAS 79784-22-8
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Peso molecular 354.49
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Fòrmula C22H30N2O2
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SMILES
CC(C)NCCCCOC1=C(C)N=C(CC2=CC=CC=C2)C3=C1COC3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Zehender M, et al. Efficacy and tolerance of the new class IB antiarrhythmic barucainide: an intravenous dose-finding study. Clin Pharmacol Ther. 1991 Jan;49(1):78-85. [Content Brief]
[2]. Takanaka C, Singh BN. Barucainide, a novel class Ib antiarrhythmic agent with a slow kinetic property: electrophysiologic observations in isolated canine and rabbit cardiac muscle. Am Heart J. 1990 May;119(5):1050-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Barucainide Related Classifications
HY-106718 Related Classifications
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