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Referencia número: HY-183702

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BDM91531

BDM91531 is a AcrB inhibitor with an EC₅₀ of 0.16 μM against E. coli. BDM91531 acts as an antibiotic potentiator to restore the sensitivity of wild-type Escherichia coli to multiple AcrB substrate antibiotics. BDM91531 exhibits antibacterial activity. BDM91531 can be used in the research of bacterial infections.

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No. CAS: 2892824-73-4
Fòrmula: C₂₀H₂₁ClN₄
Peso molecular:352.86

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Please store the product under the recommended conditions in the Certificate of Analysis.

BDM91531 Chemical Structure

No. CAS: 2892824-73-4

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In Vitro

BDM91531 (Compound 6) (4.5 h) potently enhances the activity of AcrB substrate antibiotics in wild-type E. coli BW25113 by inhibiting the AcrAB-TolC efflux pump, with an EC₉₀ of 0.24 μM against pyridomycin^[1].
BDM91531 (20 min) binds tightly to purified wild-type E. coli AcrB, induces its thermal stability, with a half-effective concentration of approximately 156 nM^[1].
BDM91531 (0-5 μM; 16 h) induces concentration-dependent growth inhibition in E. coli BW25113ΔacrB complementarily expressing wild-type AcrB in the presence of Erythromycin (HY-B0220), and its activity depends on the negatively charged residues (E947, D951) at the cytoplasmic rim of AcrB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2892824-73-4
Peso molecular 352.86
Fòrmula C₂₀H₂₁ClN₄
SMILES

NCC1=CC(C(C=C2)=CC3=C2N=C(N4CCNCC4)C(Cl)=C3)=CC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Börnsen C, et al. Molecular mechanism of transition-state inhibitors of bacterial antibiotic efflux pumps. NPJ Antimicrob Resist. 2026;4(1):35. Published 2026 May 4. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BDM91531

Ver todos los productos específicos de isoformas Antibiotic

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BDM91531 Related Classifications

HY-183702 Related Classifications