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Referencia número: HY-111837

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BI1071

BI1071 is an orally active Nur77-Bcl-2 apoptotic pathway modulator. BI1071 can bind to Nur77-LBD protein with a K_d of 0.17 μM. BI1071 can activate Nur77 signaling and induce apoptosis by translocating to mitochondria where it interacts with Bcl-2. BI1071 can inhibit tumor growth in SW620 xenograft mice model. BI1071 can be used for research of colon cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₅H₁₉F₃N₂O₃S
Peso molecular:484.49

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

BI1071 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Referencias
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Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

Nur77/NR4A1

Bcl-2

Ver todos los productos específicos de isoformas Nuclear Hormone Receptor 4A/NR4A :

Ver todos los productos específicos de isoformas Bcl-2 Family :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	0.17 μM Compound: BI1071; 8n	Cytotoxicity against human BT-549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human BT-549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
HCT-116	IC₅₀	0.27 μM Compound: BI1071; 8n	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
MCF-10A	IC₅₀	4.29 μM Compound: BI1071; 8n	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
MDA-MB-231	IC₅₀	0.22 μM Compound: BI1071; 8n	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
NCM460	IC₅₀	6.84 μM Compound: BI1071; 8n	Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
SW-620	IC₅₀	0.18 μM Compound: BI1071; 8n	Cytotoxicity against human SW-620 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human SW-620 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]

Chemical Information

Peso molecular 484.49
Fòrmula C₂₅H₁₉F₃N₂O₃S
SMILES

FC(C1=CC=C([C+](C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1)(F)F.CS(=O)([O-])=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen X, et al. BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway. Mol Cancer Ther. 2019 May;18(5):886-899. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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BI1071

Ver todos los productos específicos de isoformas Nuclear Hormone Receptor 4A/NR4A

Ver todos los productos específicos de isoformas Bcl-2 Family

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

BI1071 Related Classifications

HY-111837 Related Classifications