Boxidine
Boxidine is an orally active DHCR7 inhibitor. Boxidine inhibits DHCR7, blocks the conversion of 7-Dehydrocholesterol (HY-113279) to Cholesterol (HY-N0322), reduces serum cholesterol levels, causes accumulation of 7-dehydrocholesterol in serum and tissues, and inhibits sterol absorption. Boxidine exhibits antiproliferative and anticancer activities, with marginal activity against mouse tumors. Boxidine can be used in research related to diseases such as tumors and adrenal cancer.
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- No. CAS: 10355-14-3
- Fòrmula: C19H20F3NO
- Peso molecular:335.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
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DHCR7 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 10355-14-3
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Peso molecular 335.37
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Fòrmula C19H20F3NO
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SMILES
FC(F)(F)C1=CC=C(C=C1)C=2C=CC(OCCN3CCCC3)=CC2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Gailani S, et al. Effects of boxidine on human serum sterols and neoplasms. Clin Pharmacol Ther. 1972;13(1):91-96. [Content Brief]
[2]. Dalenc F, et al. Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties. Current medicinal chemistry. 2015;22(30):3533-49. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Boxidine Related Classifications
HY-W726633 Related Classifications
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