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Referencia número: HY-120917

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BRD1172

(Synonyms: ML320)

BRD1172 (ML320) is a selectivity GSK3β inhibitor with an IC₅₀ of 24 nM for GSK3β over CDK5. BRD1172 significantly inhibits GSK3β-mediated Tau phosphorylation in SH-SY5Y cells, and relieves negative regulation by GSK3β on β-catenin degradation and TCF/LEF promoter activities. BRD1172 can be used for Alzheimer’s disease, cardiac hypertrophy and cancers research.

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No. CAS: 1597438-86-2
Fòrmula: C₂₀H₂₀F₃N₃O₂
Peso molecular:391.39

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

BRD1172 Chemical Structure

No. CAS: 1597438-86-2

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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

GSK-3β

24 nM (IC₅₀)

Ver todos los productos específicos de isoformas GSK-3 :

Chemical Information

No. CAS 1597438-86-2
Peso molecular 391.39
Fòrmula C₂₀H₂₀F₃N₃O₂
SMILES

FC(F)(C1=C2[C@H](C3=C(C=CC=C3)OC)C4=C(CC(C)(CC4=O)C)NC2=NN1)F
Synonyms

ML320
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. An WF, et al. Discovery of Potent and Highly Selective Inhibitors of GSK3b. 2012 Apr 16 [updated 2014 May 13]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BRD1172

Ver todos los productos específicos de isoformas GSK-3

Actividad biológica

Chemical Information

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Referencias

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BRD1172 Related Classifications

HY-120917 Related Classifications