BRD2577
Based on 1 Customer Validation
BRD2577 is a selective mercaptopyruvate sulfurtransferase (3-MST) inhibitor with an IC50 of 9.9 μM. BRD2577 inhibits H2S production in colon carcinoma cells. BRD2577 exhibits weak to no significant inhibitory effect on colon cancer cell proliferation and mitochondrial activity. BRD2577 can be used for the research of colon cancer.
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- No. CAS: 353781-42-7
- Fòrmula: C15H15N3O3S
- Peso molecular:317.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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MST3 9.9 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CT26 | IC50 |
>1 mM
Compound: 13a
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Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay
Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay
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[PMID: 33856792] |
| CT26 | IC50 |
1000 μM
Compound: 13a
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Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay
Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay
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[PMID: 33856792] |
| MC-38 | IC50 |
>1 mM
Compound: 13a
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Antiproliferative activity against mouse MC38 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay
Antiproliferative activity against mouse MC38 cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay
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[PMID: 33856792] |
BRD2577 (Compound 13a) (3-300 μM; 1 h) potently inhibits recombinant human 3-MST with an IC50 of 9.9 μM and achieves ≥60% inhibition at 100 μM, and shows no activity against human recombinant CBS or CSE at concentrations up to 300 μM[1].
BRD2577 (300 μM; 2 h) does not act as an H2S scavenger at 300 μM, confirming its inhibitory effect is direct against 3-MST[1].
BRD2577 (300 μM; 4 h) inhibits H2S production in live murine CT26 and MC38 colon carcinoma cells[1].
BRD2577 (3-300 μM; 48 h) does not significantly inhibit the proliferation of murine CT26 or MC38 colon carcinoma cells at concentrations up to 300 μM after 48 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Murine CT26 colon carcinoma cells, murine MC38 colon carcinoma cells
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Concentration:3, 10, 30, 100, 300 μM
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Incubation Time:48 h
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Result:Did not significantly inhibit CT26 or MC38 cell proliferation at tested concentrations.
Showed an IC50 values were >1000 μM for both cell lines.
Chemical Information
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No. CAS 353781-42-7
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Peso molecular 317.36
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Fòrmula C15H15N3O3S
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SMILES
O=C1N=C(SCC(=O)C2=CC=C(C=C2)NC(=O)C)NC(=C1)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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