Brogidirsen
Brogidirsen (NS 089; NCNP 02) is a a dual-targeting antisense oligonucleotide. Brogidirsen can induce dystrophin protein experession. Brogidirsen can be used for the research of Duchenne muscular dystrophy.
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- No. CAS: 2409088-11-3
- Fòrmula: C280H440N119O105P23
- Peso molecular:7865.60
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Target: Dystrophin Synthesis[1]
Brogidirsen (1-10 μM; 72 h) induces dose-dependent exon 44 skipping and dystrophin protein expression in donor-derived MYOD1-UDCs, myotubes, and MYOD1-transduced fibroblasts from DMD patients amenable to exon 44 skipping[2].
Brogidirsen (1-10 μM) exhibits an EC50 of 7.12 μM for exon 44 skipping in healthy donor-derived MYOD1-UDCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:healthy donor-derived MYOD1-UDCs
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Concentration:10 μM
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Incubation Time:/
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Result:Increased exon 44 skipping expression.
Chemical Information
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No. CAS 2409088-11-3
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Peso molecular 7865.60
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Fòrmula C280H440N119O105P23
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SMILES
[Brogidirsen]
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Synonyms
NS 089; NCNP 02
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Sequence
RNA, [P-deoxy-P-(dimethylamino)](2′,3′-dideoxy-2′,3′-imino-2′,3′-seco)(2′a→5′)(m5U-m5U-G-m5U-G-m5U-C-m5U-m5U-m5U-C-m5U-m5U-C-m5U-G-m5U-m5U-A-G-C-C-A-C)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)