CBT-295
Based on 1 Customer Validation
CBT-295 is an orally active autotaxin (ATX) inhibitor. CBT-295 exhibits a significant reduction in inflammatory cytokines like TGF-β, TNF-α and IL-6 levels, also reduced bile duct proliferation marker CK-19 and lowered liver fibrosis. The reversal of liver fibrosis with CBT-295 led to a reduction in blood and brain ammonia levels. CBT-295 also reduced neuroinflammation induced by ammonia. CBT-295 is promising for research of liver cirrhosis and associated encephalopathy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.34%
- No. CAS: 1623794-90-0
- Fòrmula: C18H20ClN3O
- Peso molecular:329.82
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Chemical Information
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No. CAS 1623794-90-0
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Appearance Solid
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Peso molecular 329.82
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Fòrmula C18H20ClN3O
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Color White to off-white
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SMILES
O=C1C=C(C)N(CCCCC)C2=NC(C3=CC=C(Cl)C=C3)=CN12
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
DMSO : 50 mg/mL (151.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0320 mL | 15.1598 mL | 30.3196 mL | 75.7989 mL |
| 5 mM | 0.6064 mL | 3.0320 mL | 6.0639 mL | 15.1598 mL | |
| 10 mM | 0.3032 mL | 1.5160 mL | 3.0320 mL | 7.5799 mL | |
| 15 mM | 0.2021 mL | 1.0107 mL | 2.0213 mL | 5.0533 mL | |
| 20 mM | 0.1516 mL | 0.7580 mL | 1.5160 mL | 3.7899 mL | |
| 25 mM | 0.1213 mL | 0.6064 mL | 1.2128 mL | 3.0320 mL | |
| 30 mM | 0.1011 mL | 0.5053 mL | 1.0107 mL | 2.5266 mL | |
| 40 mM | 0.0758 mL | 0.3790 mL | 0.7580 mL | 1.8950 mL | |
| 50 mM | 0.0606 mL | 0.3032 mL | 0.6064 mL | 1.5160 mL | |
| 60 mM | 0.0505 mL | 0.2527 mL | 0.5053 mL | 1.2633 mL | |
| 80 mM | 0.0379 mL | 0.1895 mL | 0.3790 mL | 0.9475 mL | |
| 100 mM | 0.0303 mL | 0.1516 mL | 0.3032 mL | 0.7580 mL |
CBT-295 Related Classifications
HY-169004 Related Classifications
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