CDK8 ligand 2
CDK8 ligand 2 is a steroidal CDK8 and CDK19 inhibitor with IC50 values of 16 nM and 8 nM, respectively. CDK8 ligand 2 shows no activity against NEK1 (IC50 >10,000 nM). As a target protein ligand, CDK8 ligand 2 is used for the synthesis of the CDK8 PROTAC degrader (HY-111518).
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- No. CAS: 2374703-22-5
- Fòrmula: C30H42N2
- Peso molecular:430.67
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
CDK8 16 nM (IC50) |
CDK19 8 nM (IC50) |
In Vitro
Chemical Information
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No. CAS 2374703-22-5
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Peso molecular 430.67
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Fòrmula C30H42N2
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SMILES
CN(C)[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H](C5=CC6=C(C=C5)C=CN=C6)CC[C@@]4([H])[C@]3([H])CC[C@@]2([H])C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK8 ligand 2 Related Classifications
HY-184544 Related Classifications
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