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Referencia número: HY-182626

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CS1P1

CS1P1 is a brain-penetrant and selective S1PR1 antagonist and PET radiotracer, with human S1PR1 IC₅₀ values of 2.1 nM. CS1P1 binds specifically to S1PR1 to enable in vivo receptor expression quantification. CS1P1 can be used as PET radiotracer when labelled with 11C. CS1P1 can be used for the research of multiple sclerosis, neointimal hyperplasia, vascular inflammation.

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No. CAS: 1246526-29-3
Fòrmula: C₂₇H₂₃F₄N₃O₃
Peso molecular:513.48

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

CS1P1 Chemical Structure

No. CAS: 1246526-29-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

S1PR1

2.1 nM (IC₅₀)

Ver todos los productos específicos de isoformas LPL Receptor :

In Vitro

CS1P1 (2 h) potently binds to recombinant human S1PR1 with an IC₅₀ of 2.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CS1P1 (0.3 mg/kg; i.v.; single bolus) is well tolerated in male and female Sprague Dawley rats, with no observable adverse effects identified over 15 days^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male and female)^[2]
Dosage:

0.3 mg/kg
Administration:

i.v.; single bolus
Result:

Allowed all rats to survive to scheduled euthanasia.
Caused no CS1P1-related effects on body weights, hematology parameters, clinical chemistry parameters, organ weights, or gross pathology findings at either Day 2 or Day 15.
Showed no CS1P1-related histopathology.

Chemical Information

No. CAS 1246526-29-3
Peso molecular 513.48
Fòrmula C₂₇H₂₃F₄N₃O₃
SMILES

O=C(CCN(CC1=C(F)C=C(C2=NOC(C3=CC(C(F)(F)F)=C(C4=C(C)C=CC=C4)C=C3)=N2)C=C1)C)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Qiu L, et al. Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain. J Med Chem. 2023;66(7):4671-4688. [Content Brief]

[2]. Liu H, et al. Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [11C]CS1P1. Mol Imaging Biol. 2020;22(2):285-292. [Content Brief]

[3]. Castelo GP, et al. Pharmacological characterization of the CS1P1 compound as a S1P1 receptor antagonist. Ibro Neurosci Rep. 2023 Oct;15:S473-S474.

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Calculadora de molaridad

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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CS1P1

Ver todos los productos específicos de isoformas LPL Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

CS1P1 Related Classifications

HY-182626 Related Classifications