Daphnegiravone D
Daphnegiravone D (compound 70) is an HDAC6 inhibitor with anti-hepatocellular carcinoma activity. Daphnegiravone D can induce apoptosis and selectively inhibit the proliferation of liver cancer cells through the p38 and JNK MAPK pathways.
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- No. CAS: 2581826-37-9
- Fòrmula: C26H28O6
- Peso molecular:436.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | IC50 |
2.31 μM
Compound: 20
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Cytotoxicity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
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[PMID: 36549116] |
| HepG2 | IC50 |
>50 μM
Compound: 20
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
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[PMID: 36549116] |
Chemical Information
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No. CAS 2581826-37-9
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Peso molecular 436.50
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Fòrmula C26H28O6
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SMILES
O=C1C(OC)=C(C2=CC(C/C=C(C)\C)=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C31
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Wang D, et al. A new Prenylated Flavonoid induces G0/G1 arrest and apoptosis through p38/JNK MAPK pathways in Human Hepatocellular Carcinoma cells. Sci Rep. 2017 Jul 18;7(1):5736. [Content Brief]
[2]. Chen JJ, et al. Network pharmacology predicted HDAC6 as a potential target of flavones from Daphne giraldii on hepatocellular carcinoma. Nat Prod Res. 2021 Sep;35(18):3171-3175. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Daphnegiravone D Related Classifications
HY-N13121 Related Classifications
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