Dinaline
Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer.
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- No. CAS: 58338-59-3
- Fòrmula: C13H13N3O
- Peso molecular:227.26
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
12.6 μM
Compound: Dinaline
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Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
| HepG2 | EC50 |
28.2 μM
Compound: Dinaline
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Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
Dinaline (0.47-15 µg/mL; 48, 27 h) shows cytotoxicity for SW707, SW948 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW707, SW948 cells
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Concentration:0.47, 0.95, 1.9, 3.8, 7.5, 15 µg/mL
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Incubation Time:48, 72 h
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Result:Inhibited cell growth with IC50s of 2.2, 1.0 µg/mL at 48 h and 1.2, 0.8 µg/mL at 72 h for SW707, SW948 cells, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:140-160 g, male Sprague-Dawley rats[1]
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Dosage:5.9, 7.7, 10 mg/kg
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Administration:P.o.; 5 days per week for 10 weeks
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Result:Showed significant tumor growth inhibition in a dose-dependent manner with the ratio of median tumor volume of (T/C%) values of 0.4, 16 and 10.6 at 10, 7.7 and 5.9 mg/kg respectively.
Chemical Information
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No. CAS 58338-59-3
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Peso molecular 227.26
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Fòrmula C13H13N3O
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SMILES
O=C(C1=CC=C(C=C1)N)NC2=C(N)C=CC=C2
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Synonyms
GOE 1734; PD 104 208; NSC 328786
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dinaline Related Classifications
HY-W326094 Related Classifications
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