Divarin
Based on 1 Customer Validation
Divarin (5-Propylbenzene-1,3-diol) is an important precursor and intermediate in the synthesis of cannabinoids, and is present in certain bacteria and lichens. Divarin exhibits antioxidant activity. Divarin acts as an electron acceptor to directly scavenge superoxide anions and modulates the transcription of oxidative stress genes such as soxS, thereby enhancing bacterial resistance to late-stage reactive oxygen species (ROS) through a non-enzymatic mechanism. Divarin can be used in research on antioxidant development.
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- Pureza : 99.35%
- No. CAS: 500-49-2
- Fòrmula: C9H12O2
- Peso molecular:152.19
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Almacenamiento:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Divarin (1 μM-1 mM; pre-incubation for 60 min and 60 min under PQ stimulation) modulates soxS gene expression and enhances antioxidant stress survival in PQ (HY-B0864A)-treated E. coli K12 MG1655 psoxS'::luxCDABE-Amp bacterial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E. coli K12 MG1655 psoxS'::luxCDABE-Amp strain
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Concentration:1 μM, 10 μM, 0.1 mM, 1 mM
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Incubation Time:pre-incubated for 60 minutes, followed by paraquat (PQ) stimulation for 60 minutes
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Result:Paradoxically and significantly increased bacterial survival under PQ-induced oxidative stress (increasing the number of surviving cells by 16.1% to 40.9% compared to the control group).
Chemical Information
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No. CAS 500-49-2
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Appearance Solid
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Peso molecular 152.19
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Fòrmula C9H12O2
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Color Light brown to brown
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SMILES
OC1=CC(CCC)=CC(O)=C1
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Synonyms
5-Propylbenzene-1,3-diol
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (657.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.5707 mL | 32.8537 mL | 65.7073 mL | 164.2683 mL |
| 5 mM | 1.3141 mL | 6.5707 mL | 13.1415 mL | 32.8537 mL | |
| 10 mM | 0.6571 mL | 3.2854 mL | 6.5707 mL | 16.4268 mL | |
| 15 mM | 0.4380 mL | 2.1902 mL | 4.3805 mL | 10.9512 mL | |
| 20 mM | 0.3285 mL | 1.6427 mL | 3.2854 mL | 8.2134 mL | |
| 25 mM | 0.2628 mL | 1.3141 mL | 2.6283 mL | 6.5707 mL | |
| 30 mM | 0.2190 mL | 1.0951 mL | 2.1902 mL | 5.4756 mL | |
| 40 mM | 0.1643 mL | 0.8213 mL | 1.6427 mL | 4.1067 mL | |
| 50 mM | 0.1314 mL | 0.6571 mL | 1.3141 mL | 3.2854 mL | |
| 60 mM | 0.1095 mL | 0.5476 mL | 1.0951 mL | 2.7378 mL | |
| 80 mM | 0.0821 mL | 0.4107 mL | 0.8213 mL | 2.0534 mL | |
| 100 mM | 0.0657 mL | 0.3285 mL | 0.6571 mL | 1.6427 mL |
Divarin Related Classifications
HY-W110493 Related Classifications
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Keywords
- Divarin
- 500-49-2
- 5-Propylbenzene-1,3-diol
- Drug Intermediate
- Endogenous Metabolite
- Reactive Oxygen Species (ROS)
- Bacterial
- E. coli
- alkylresorcinol
- bacterial cell viability
- nitroblue tetrazolium
- oxidative stress
- paraquat
- sox regulon transcription
- soxS gene expression
- soxS-dependent bioluminescence
- superoxide anion
- Inhibitor
- inhibitor
- inhibit