DM3
Based on 1 Customer Validation
DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs).
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- Pureza: 95.59%
- No. CAS: 796073-54-6
- Fòrmula: C37H52ClN3O10S
- Peso molecular:766.34
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Maytansinoids |
DM3 contains disulfide bonds or thiol groups, which can be covalently linked to monoclonal antibodies (mAb)[1].
DM3 exerts a strong anti-mitotic effect by inhibiting microtubule dynamic instability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 796073-54-6
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Appearance Solid
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Peso molecular 766.34
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Fòrmula C37H52ClN3O10S
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Color White to off-white
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SMILES
C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(S)C)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
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Synonyms
Maytansinoid DM3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (130.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [Content Brief]
[2]. Griffin P, et al. High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model. Cancer Cell Int. 2023 Apr 5;23(1):60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3049 mL | 6.5245 mL | 13.0490 mL | 32.6226 mL |
| 5 mM | 0.2610 mL | 1.3049 mL | 2.6098 mL | 6.5245 mL | |
| 10 mM | 0.1305 mL | 0.6525 mL | 1.3049 mL | 3.2623 mL | |
| 15 mM | 0.0870 mL | 0.4350 mL | 0.8699 mL | 2.1748 mL | |
| 20 mM | 0.0652 mL | 0.3262 mL | 0.6525 mL | 1.6311 mL | |
| 25 mM | 0.0522 mL | 0.2610 mL | 0.5220 mL | 1.3049 mL | |
| 30 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0874 mL | |
| 40 mM | 0.0326 mL | 0.1631 mL | 0.3262 mL | 0.8156 mL | |
| 50 mM | 0.0261 mL | 0.1305 mL | 0.2610 mL | 0.6525 mL | |
| 60 mM | 0.0217 mL | 0.1087 mL | 0.2175 mL | 0.5437 mL | |
| 80 mM | 0.0163 mL | 0.0816 mL | 0.1631 mL | 0.4078 mL | |
| 100 mM | 0.0130 mL | 0.0652 mL | 0.1305 mL | 0.3262 mL |
DM3 Related Classifications
HY-130080 Related Classifications
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