DML3
DML3, a 5-methylcytosine DNA glycosylase, is a DNA demethylating agent. DML3 specifically recognizes and excises 5-methylcytosine (5-meC) from DNA through a base excision repair mechanism. DML3 is promising for research of plant epigenetic regulation and cancers.
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- No. CAS: 1230-77-9
- Fòrmula: C18H19NO2
- Peso molecular:281.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L929 | CC50 |
>200 μM
Compound: 20
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Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 31000155] |
| L929 | CC50 |
200 μM
Compound: 20
|
Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 31000155] |
Chemical Information
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No. CAS 1230-77-9
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Peso molecular 281.36
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Fòrmula C18H19NO2
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SMILES
O=C(C=CC1=CC=C(C=C1)N(C)C)C2=CC=C(OC)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Ortega-Galisteo AP, et al. Arabidopsis DEMETER-LIKE proteins DML2 and DML3 are required for appropriate distribution of DNA methylation marks. Plant Mol Biol. 2008 Aug;67(6):671-81. [Content Brief]
[2]. Len JM, et al. A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe. Molecules. 2021 Jul 11;26(14):4214. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DML3 Related Classifications
HY-W974306 Related Classifications
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