DPO-1
Based on 1 publication(s) in Google Scholar
DPO-1 is a potent Kv1.5 and Kv1.3 (EC50 = 3.1 μM) channels inhibitor with potential immunomodulatory and anti-inflammatory effects. DPO-1 reduces Kv1.3 current density, blunts Ca2+ influx in Ca2+-depleted Jurkat cells, and inhibits IL-2 secretion in activated Jurkat cells. DPO-1 inhibits Uric acid sodium (HY-B2130A) (MSU)-induced NLRP3 inflammasome activation by blocking Kv1.5-mediated K+ efflux. DPO-1 can be used for the study of immunologic disorders and atrial fibrillation.
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- Pureza: 98.39%
- No. CAS: 43077-30-1
- Fòrmula: C22H29OP
- Peso molecular:340.44
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Publications Citing Use of MedChemExpress (MCE) DPO-1
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
30 nM
Compound: 1, DPO-1
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Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay
Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay
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[PMID: 20304642] |
DPO-1 (1-10 μM) inhibits outward K+ currents in mesenteric artery VSMCs from wild-type (Kcna5+/+) mice, with a more potent inhibitory effect than in VSMCs from Kcna5-/- mice[1].
DPO-1 (10 μM, 30 min) induces stable vasocontraction in mesenteric artery rings without PVAT in Kcna5+/+ and Kcna5-/- mice[1].
DPO-1 (0.3-30 μM) blocks Kv1.3 current in a voltage-dependent and concentration-dependent manner in Jurkat cells and human peripheral blood T cells, with IC50 values of 2.58 μM (Jurkat cells) and 3.11 μM (human peripheral blood T cells)[2].
DPO-1 (1-10 μM, 24 h) decreases Kv1.3 current density at +40 mV in Jurkat cells and reduces Kv1.3 protein expression[2].
DPO-1 (0.1-3 μM, 24 h) blunts Ca2+ influx in Ca2+-depleted Jurkat cells induced by Thapsigargin (TG) (HY-13433)[2].
DPO-1 (3-10 μM, 24 h) inhibits IL-2 secretion in activated Jurkat cells[2].
DPO-1 (0-100 μM, 6 h) concentration-dependently reduces caspase-1 (p20) and IL-1β (p17) protein levels, prevents intracellular K+ concentration decrease, suppresses ASC oligomerization and speck formation in LPS (HY-D1056)-primed J774.1 mouse macrophages[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 43077-30-1
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Appearance Solid
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Peso molecular 340.44
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Fòrmula C22H29OP
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Color White to off-white
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SMILES
CC([C@H]1[C@@H](P(C2=CC=CC=C2)(C3=CC=CC=C3)=O)C[C@H](C)CC1)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 10 mg/mL (29.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (283 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Tsvetkov D, et al. The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of Vascular Tone. Front Physiol. 2016 Aug 4;7:335. [Content Brief]
[2]. Zhao N, et al. Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. PLoS One. 2013 May 22;8(5):e64629. [Content Brief]
[3]. Li P, et al. Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. Mol Biol Rep. 2022 Jul;49(7):5939-5952. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9374 mL | 14.6869 mL | 29.3738 mL | 73.4344 mL |
| 5 mM | 0.5875 mL | 2.9374 mL | 5.8748 mL | 14.6869 mL | |
| 10 mM | 0.2937 mL | 1.4687 mL | 2.9374 mL | 7.3434 mL | |
| 15 mM | 0.1958 mL | 0.9791 mL | 1.9583 mL | 4.8956 mL | |
| 20 mM | 0.1469 mL | 0.7343 mL | 1.4687 mL | 3.6717 mL | |
| 25 mM | 0.1175 mL | 0.5875 mL | 1.1750 mL | 2.9374 mL |
DPO-1 Related Classifications
HY-100712 Related Classifications
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