DU172
DU172 is a ligand for the adenosine A1 receptor (Adenosine A1 Receptor), with an IC50 of 24.9 nM against A1AR and an IC50 of 0.42 μM against A2AAR.
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- No. CAS: 321907-03-3
- Fòrmula: C24H30FN5O5S
- Peso molecular:519.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
DU172 (Compound 23a) potently binds to the A1 adenosine receptor on the cell membrane of DDT1 MF-2, with an IC50 of 24.9 nM for inhibiting [3H]DPCPX binding[2].
DU172 binds to the A2A adenosine receptor on the membrane of PC-12 cells, with an IC50 of 0.42 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 321907-03-3
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Peso molecular 519.59
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Fòrmula C24H30FN5O5S
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SMILES
O=C(NCCCN1C(=O)N(C(=O)C=2NC(=NC21)C3CCCCC3)CCC)C4=CC=C(C=C4)S(=O)(=O)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
[1]. Glukhova A, et al. Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity. Cell. 2017;168(5):867-877.e13. [Content Brief]
[2]. Beauglehole AR, et al. Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor. J Med Chem. 2000;43(26):4973-4980. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DU172 Related Classifications
HY-165509 Related Classifications
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