EJMC-1
Based on 1 Customer Validation
EJMC-1 is a moderately potent TNF-α inhibitor with an IC50 value of 42 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.08%
- No. CAS: 397281-20-8
- Fòrmula: C17H11ClN2O4S
- Peso molecular:374.80
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
42.3 μM
Compound: 1
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Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay system
Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay system
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[PMID: 25078315] |
| HeLa | IC50 |
45.7 μM
Compound: 1
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Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISA
Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISA
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[PMID: 25078315] |
Chemical Information
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No. CAS 397281-20-8
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Appearance Solid
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Peso molecular 374.80
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Fòrmula C17H11ClN2O4S
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Color Light yellow to yellow
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SMILES
O=C1NC2=CC=C(S(=O)(NC3=CC=C(C(Cl)=C3)O)=O)C4=C2C1=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (333.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6681 mL | 13.3404 mL | 26.6809 mL | 66.7022 mL |
| 5 mM | 0.5336 mL | 2.6681 mL | 5.3362 mL | 13.3404 mL | |
| 10 mM | 0.2668 mL | 1.3340 mL | 2.6681 mL | 6.6702 mL | |
| 15 mM | 0.1779 mL | 0.8894 mL | 1.7787 mL | 4.4468 mL | |
| 20 mM | 0.1334 mL | 0.6670 mL | 1.3340 mL | 3.3351 mL | |
| 25 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6681 mL | |
| 30 mM | 0.0889 mL | 0.4447 mL | 0.8894 mL | 2.2234 mL | |
| 40 mM | 0.0667 mL | 0.3335 mL | 0.6670 mL | 1.6676 mL | |
| 50 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 60 mM | 0.0445 mL | 0.2223 mL | 0.4447 mL | 1.1117 mL | |
| 80 mM | 0.0334 mL | 0.1668 mL | 0.3335 mL | 0.8338 mL | |
| 100 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6670 mL |
EJMC-1 Related Classifications
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