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Referencia número: HY-184150

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EN10

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4.

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No. CAS: 2093466-80-7
Fòrmula: C₂₁H₂₃N₃O
Peso molecular:333.43

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

EN10 Chemical Structure

No. CAS: 2093466-80-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4^[1].

IC₅₀ & Target

^[1]

KLHL41

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In Vitro

EN10 (5-15 μM; 30 min) selectively binds to KLHL41 (but not KLHL40) in live RH30 human muscle rhabdomyosarcoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

No. CAS 2093466-80-7
Peso molecular 333.43
Fòrmula C₂₁H₂₃N₃O
SMILES

[C@@H]1(C2=CC=CC=C2)OCC[C@H]1CNCC3=CNN=C3C4=CC=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yim J, et al. Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation. Nat Commun. 2026;17(1):4551. Published 2026 May 26. [Content Brief]

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Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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EN10

Ver todos los productos específicos de isoformas Ligands for E3 Ligase

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