Ethambutol-d4
Based on 1 Customer Validation
Ethambutol-d4 is the deuterium labeled Ethambutol. Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.12%
- No. CAS: 1129526-19-7
- Fòrmula: C10H20D4N2O2
- Peso molecular:208.33
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1129526-19-7
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Unlabeled CAS 1070-11-7
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Appearance Solid
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Peso molecular 208.33
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Fòrmula C10H20D4N2O2
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Color White to off-white
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SMILES
CC[C@@H](CO)NC([2H])([2H])C([2H])([2H])N[C@H](CO)CC
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Synonyms
Emb-d4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (480.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Ethambutol. Tuberculosis (Edinb), 2008. 88(2): p. 102-5. [Content Brief]
[3]. Rastogi, N., V. Labrousse, and K.S. Goh, In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr Microbiol, 1996. 33(3): p. 167-75. [Content Brief]
[4]. Kaur, D. and G.K. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17(1): p. 51-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8001 mL | 24.0004 mL | 48.0008 mL | 120.0019 mL |
| 5 mM | 0.9600 mL | 4.8001 mL | 9.6002 mL | 24.0004 mL | |
| 10 mM | 0.4800 mL | 2.4000 mL | 4.8001 mL | 12.0002 mL | |
| 15 mM | 0.3200 mL | 1.6000 mL | 3.2001 mL | 8.0001 mL | |
| 20 mM | 0.2400 mL | 1.2000 mL | 2.4000 mL | 6.0001 mL | |
| 25 mM | 0.1920 mL | 0.9600 mL | 1.9200 mL | 4.8001 mL | |
| 30 mM | 0.1600 mL | 0.8000 mL | 1.6000 mL | 4.0001 mL | |
| 40 mM | 0.1200 mL | 0.6000 mL | 1.2000 mL | 3.0000 mL | |
| 50 mM | 0.0960 mL | 0.4800 mL | 0.9600 mL | 2.4000 mL | |
| 60 mM | 0.0800 mL | 0.4000 mL | 0.8000 mL | 2.0000 mL | |
| 80 mM | 0.0600 mL | 0.3000 mL | 0.6000 mL | 1.5000 mL | |
| 100 mM | 0.0480 mL | 0.2400 mL | 0.4800 mL | 1.2000 mL |
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