FD2024
FD2024 is a pan-PIM kinase inhibitor with IC50 values of 0.17 nM, 1.86 nM, and 0.38 nM against PIM-1, PIM-2, and PIM-3, respectively. FD2024 induces cell apoptosis. FD2024 inhibits the phosphorylation of mTOR, p70S6K, S6, 4EBP1, and BAD proteins. FD2024 exhibits anti-acute myeloid leukemia activity. FD2024 can be used in studies related to acute myeloid leukemia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C22H22F2N6O2
- Peso molecular:440.45
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
PIM1 0.17 nM (IC50) |
PIM2 1.86 nM (IC50) |
PIM3 0.38 nM (IC50) |
FD2024 potently inhibits PIM-1, PIM-2, and PIM-3 kinases with IC50 values of 0.17 nM, 1.86 nM, and 0.38 nM, respectively[1].
FD2024 (48 h) potently inhibits the proliferation of multiple human AML cell lines, with IC50 values ranging from 0.02 μM (MOLM-13) to 0.25 μM (MOLM-16)[1].
FD2024 (1-5 μM; 48 h) dose-dependently induces apoptosis in human AML cell lines, with significantly higher apoptotic rates at 5 μM compared to 1 μM in both MV-4-11 and EOL-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MV-4-11
-
Concentration:1 μM, 5 μM
-
Incubation Time:48 h
-
Result:Induced apoptosis in 14.9% of MV-4-11 cells at 1 μM.
Induced apoptosis in 83.8% of MV-4-11 cells at 5 μM.
-
Cell Line:EOL-1, MV-4-11
-
Concentration:0.1, 0.2, 0.5, 1.0, 2.0, 5.0 μM
-
Incubation Time:3 h
-
Result:Dose-dependently inhibited the phosphorylation of mTOR, p70S6K, S6, 4EBP1, and BAD proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:NSFG (NOD-PrkdcscidB6-IL2rgnullNh) (male, 6-8 weeks old, intravenous transplantation of luciferase-expressing MV-4-11 cells)[1]
-
Dosage:7.5 mg/kg; 15 mg/kg
-
Administration:i.p.; daily; 14 days
-
Result:Suppressed leukemic progression via reduced in vivo bioluminescence intensity.
Prolonged overall survival to 44 days (all vehicle control mice died by day 36).
Showed no treatment-related organ toxicity in liver, heart, spleen, lungs, and kidneys.
Maintained stable body weight throughout the study period.
Chemical Information
-
Peso molecular 440.45
-
Fòrmula C22H22F2N6O2
-
SMILES
FC(C=CC=C1F)=C1C2=NC(C(NC3=C(O[C@@H]4CC[C@@H](N)CC4)C=CN=C3)=O)=C(N)N=C2
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FD2024 Related Classifications
HY-181925 Related Classifications
Powered by Bioz