Fenethazine
Fenethazine (Phenethazine) is a compound with antihistamine activity. It is an effective antihistamine. Its congeners also have anticholinergic effects and can be used to inhibit Parkinson's disease.
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- No. CAS: 522-24-7
- Fòrmula: C16H18N2S
- Peso molecular:270.39
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 522-24-7
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Peso molecular 270.39
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Fòrmula C16H18N2S
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SMILES
CN(C)CCN1C2=C(SC3=CC=CC=C13)C=CC=C2
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Synonyms
Phenethazine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)