HM03
Based on 4 publication(s) in Google Scholar
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.51%
- No. CAS: 500565-15-1
- Fòrmula: C26H27ClN4O2
- Peso molecular:462.97
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) HM03
More
Actividad biológica
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HSPA5 |
HM03 (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells[1].
HM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins[1].
HM03 exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:0.1, 1, 10, 25, 50 μM
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Incubation Time:72 hours
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Result:Exhibited prominent inhibition effect (18% survival at 25 µM).
Chemical Information
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No. CAS 500565-15-1
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Appearance Solid
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Peso molecular 462.97
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Fòrmula C26H27ClN4O2
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Color Pink to red
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SMILES
OC1=CC=C(NC2=C(C=C(OC)C=C3)C3=NC4=CC(Cl)=CC=C42)C=C1CN5CCN(C)CC5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Proc Natl Acad Sci U S A
COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis. [Abstract]2023 May 23;120(21):e2217119120. PMID: 37186819 -
Bioorg Chem
Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]2024 Jun:147:107412. PMID: 38696845 -
iScience
Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish. [Abstract]2023 Oct 13;26(11):108207. PMID: 37942006 -
bioRxiv
2025 Dec 9:2025.12.07.692843. PMID: 41427295
Solvente y solubilidad
DMSO : 100 mg/mL (216.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1600 mL | 10.7998 mL | 21.5997 mL | 53.9992 mL |
| 5 mM | 0.4320 mL | 2.1600 mL | 4.3199 mL | 10.7998 mL | |
| 10 mM | 0.2160 mL | 1.0800 mL | 2.1600 mL | 5.3999 mL | |
| 15 mM | 0.1440 mL | 0.7200 mL | 1.4400 mL | 3.5999 mL | |
| 20 mM | 0.1080 mL | 0.5400 mL | 1.0800 mL | 2.7000 mL | |
| 25 mM | 0.0864 mL | 0.4320 mL | 0.8640 mL | 2.1600 mL | |
| 30 mM | 0.0720 mL | 0.3600 mL | 0.7200 mL | 1.8000 mL | |
| 40 mM | 0.0540 mL | 0.2700 mL | 0.5400 mL | 1.3500 mL | |
| 50 mM | 0.0432 mL | 0.2160 mL | 0.4320 mL | 1.0800 mL | |
| 60 mM | 0.0360 mL | 0.1800 mL | 0.3600 mL | 0.9000 mL | |
| 80 mM | 0.0270 mL | 0.1350 mL | 0.2700 mL | 0.6750 mL | |
| 100 mM | 0.0216 mL | 0.1080 mL | 0.2160 mL | 0.5400 mL |
HM03 Related Classifications
HY-125974 Related Classifications
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