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Referencia número: HY-170598

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HP211206

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Based on 1 Customer Validation

HP211206 is a SARS-CoV-2 main protease (M^pro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 M^pro and its drug-resistant mutants. HP211206 has an IC₅₀ of 181.9 nM and a DC₅₀ of 621 nM for M^pro. HP211206 has antiviral activity.
(Pink: SARS-CoV-2 Mpro ligand (HY-170599); Blue: Cereblon ligand (HY-41547); Black: linker (HY-B0236)).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3119106-17-8
Fòrmula: C₄₂H₅₅F₂N₉O₁₀
Peso molecular:883.94

Almacenamiento:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Data Sheet (266 KB)

HP211206 Chemical Structure

No. CAS: 3119106-17-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

HP211206 is a SARS-CoV-2 main protease (M^pro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 M^pro and its drug-resistant mutants. HP211206 has an IC₅₀ of 181.9 nM and a DC₅₀ of 621 nM for M^pro. HP211206 has antiviral activity^[1]. (Pink: SARS-CoV-2 Mpro ligand (HY-170599); Blue: Cereblon ligand (HY-41547); Black: linker (HY-B0236)).

IC₅₀ & Target

IC₅₀: 181.9 nM (SARS-CoV-2 M^pro);
DC₅₀: 621 nM (SARS-CoV-2 M^pro)^[1].

Ver todos los productos específicos de isoformas PROTACs :

Chemical Information

No. CAS 3119106-17-8
Appearance Solid
Peso molecular 883.94
Fòrmula C₄₂H₅₅F₂N₉O₁₀
Color Light yellow to green yellow
SMILES

O=C(CCC1N2C(C(C(NCCCCCC(N(C)[C@@H](C)C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N[C@H](C#N)C[C@H]4C(NCC4)=O)=O)C[C@@H](OC(F)F)C3)=O)=O)=O)=CC=C5)=C5C2=O)=O)NC1=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Sang X, et al. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells. J Am Chem Soc. 2023 Dec 20;145(50):27248-27253. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
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HP211206

Ver todos los productos específicos de isoformas PROTACs

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

HP211206 Related Classifications

HY-170598 Related Classifications