IMM-01
Based on 1 Customer Validation
IMM-01 is a mammalian Diaphanous (mDia)-related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.12%
- No. CAS: 218795-74-5
- Fòrmula: C12H17N3O2S
- Peso molecular:267.35
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
IMM-01 (100 μM; 1h) induces microtubule stabilization in SW480 colon carcinoma cells[1].
IMM-01 (10 μM) significantly induces LacZ expression in NIH 3T3-SRE-LacZ cells[1].
IMM-01 (1-100 μM; 48 hours) induces caspase-3 cleavage during induction of apoptosis in NIH 3T3 cells and SW480 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH 3T3 cells and SW480 cells
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Concentration:1 μM, 10 μM, or 100 μM
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Incubation Time:48 hours
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Result:Induced caspase-3 cleavage.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Athymic nude female mice (6 to 8 weeks) implanted with SW480 cells[1]
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Dosage:5 mg/kg, 25 mg/kg
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Administration:i.v.; 2 times a week; for 3 weeks
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Result:Slowed tumor growth in a dose-dependent manner when administered intravenously via the tail vein.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 218795-74-5
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Appearance Solid
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Peso molecular 267.35
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Fòrmula C12H17N3O2S
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Color Light yellow to light brown
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SMILES
OC1=CC=C(/C=N/NC(NC(C)(C)C)=S)C(O)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 125 mg/mL (467.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7404 mL | 18.7021 mL | 37.4042 mL | 93.5104 mL |
| 5 mM | 0.7481 mL | 3.7404 mL | 7.4808 mL | 18.7021 mL | |
| 10 mM | 0.3740 mL | 1.8702 mL | 3.7404 mL | 9.3510 mL | |
| 15 mM | 0.2494 mL | 1.2468 mL | 2.4936 mL | 6.2340 mL | |
| 20 mM | 0.1870 mL | 0.9351 mL | 1.8702 mL | 4.6755 mL | |
| 25 mM | 0.1496 mL | 0.7481 mL | 1.4962 mL | 3.7404 mL | |
| 30 mM | 0.1247 mL | 0.6234 mL | 1.2468 mL | 3.1170 mL | |
| 40 mM | 0.0935 mL | 0.4676 mL | 0.9351 mL | 2.3378 mL | |
| 50 mM | 0.0748 mL | 0.3740 mL | 0.7481 mL | 1.8702 mL | |
| 60 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5585 mL | |
| 80 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1689 mL | |
| 100 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9351 mL |
IMM-01 Related Classifications
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