INCB106385
INCB106385 is an orally active A2A/A2B adenosine receptor antagonist, with an IC50 value of 4.4 nM for cAMP inhibition at the A2A adenosine receptor and an IC50 value of 6.4 nM for cAMP inhibition at the A2B adenosine receptor. INCB106385 inhibits the pCREB signaling pathway in immune cells, blocks adenosine-mediated immunosuppression in the tumor microenvironment, and induces tumor regression. INCB106385 exhibits efficacy as a monotherapy or in combination with anti-PD-1 antibodies in colon cancer models. INCB106385 can be used for the research of colon cancer.
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- No. CAS: 2408260-34-2
- Fòrmula: C23H17N9O
- Peso molecular:435.44
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
A2AR |
A2BR |
In Vitro
INCB106385 (compound 36) inhibits cAMP production in A2A-overexpressing HEK293 cells with an IC50 of 4.4 nM[1].
INCB106385 inhibits cAMP production in A2B-overexpressing HEK293 cells with an IC50 of 6.4 nM[1].
INCB106385 inhibits phospho-CREB levels in human whole blood CD4+ T cells with an IC50 of 4.1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
Chemical Information
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No. CAS 2408260-34-2
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Peso molecular 435.44
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Fòrmula C23H17N9O
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SMILES
N#CC1=CC=CC(C2=C(C(C=C3)=NN(C)C3=O)N4C(C(N)=N2)=NC(CC5=NC=CC=C5)=N4)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
INCB106385 Related Classifications
HY-184213 Related Classifications
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