KDEL
KDEL is a tetrapeptide serving as an endoplasmic reticulum (ER) retrieval/retention signal. KDEL can target and deliver exogenous antigen peptides to the ER, significantly enhance and prolong MHC class I molecule presentation, and effectively boost anti-tumor immune responses.
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- No. CAS: 113516-56-6
- Fòrmula: C21H37N5O9
- Peso molecular:503.55
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (6-8 weeks old) with E.G7‑OVA tumor challenge[1]
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Dosage:10 μM OVA257‑264‑KDEL peptide
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Administration:subcutaneous injection ( days 0 and 7)
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Result:Induced greatly enhanced specific CD8+ cytotoxic T lymphocyte (CTL) responses, remarkably prolonged surface MHC class I/peptide complex display, and resulted in significant inhibition of E.G7‑OVA tumor growth in vivo compared with OVA257‑264 or OVA257‑264‑TEWT peptide groups.
Chemical Information
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No. CAS 113516-56-6
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Peso molecular 503.55
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Fòrmula C21H37N5O9
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Sequence
Lys-Asp-Glu-Leu
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Sequence Shortening
KDEL
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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