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Referencia número: HY-149462

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KN1022

KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC₅₀ of 0.24 μM.

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No. CAS: 205255-11-4
Fòrmula: C₂₁H₂₂N₆O₅
Peso molecular:438.44

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

KN1022 Chemical Structure

No. CAS: 205255-11-4

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Actividad biológica

Descripciòn

KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC₅₀ of 0.24 μM^[1].

Ver todos los productos específicos de isoformas PDGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.7 μM Compound: KN1022	Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells	[PMID: 12941321]
CHO	IC₅₀	0.7 μM/L Compound: KN1022	Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells	[PMID: 12941321]
PASMC	IC₅₀	0.1 μM Compound: KN1022	Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells	[PMID: 12086491]
PASMC	IC₅₀	0.1 μM/L Compound: KN1022	Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells	[PMID: 12086491]

Chemical Information

No. CAS 205255-11-4
Peso molecular 438.44
Fòrmula C₂₁H₂₂N₆O₅
SMILES

O=C(N1CCN(CC1)C2=C3C=C(OC)C(OC)=CC3=NC=N2)NC4=CC=C([N+]([O-])=O)C=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kenji Matsuno, et al. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J Med Chem. 2002 Jul 4;45(14):3057-66. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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Chemical Information
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Referencias

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KN1022

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AG 1295

SU4312

PDGFRα kinase inhibitor 1

Tovetumab

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Tyrphostin AG1433

Ver todos los productos específicos de isoformas PDGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

KN1022

TAK-593

Olaratumab

Vorolanib

Toceranib

SU16f

Seralutinib

AG 1295

SU4312

PDGFRα kinase inhibitor 1

Tovetumab

SU14813 maleate

Tyrphostin AG1433

Ver todos los productos específicos de isoformas PDGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

KN1022 Related Classifications

HY-149462 Related Classifications