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Referencia número: HY-19418

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KRP-101

KRP-101 is a compound that regulates the expression of genes related to lipid metabolism. It is a PPARα agonist that can highly sensitively regulate the expression of genes such as apolipoprotein A-IV, which may be related to lowering serum triglycerides and increasing HDL.

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No. CAS: 311770-26-0
Fòrmula: C₂₆H₂₆FNO₅
Peso molecular:451.49

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

KRP-101 Chemical Structure

No. CAS: 311770-26-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas PPAR :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	0.014 μM Compound: 7	Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	[PMID: 12951082]
CHO-K1	EC₅₀	0.667 μM Compound: 7	Transcriptional activation activity on human I272F-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells Transcriptional activation activity on human I272F-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	[PMID: 12951082]
CHO-K1	EC₅₀	0.00061 μM Compound: 7	Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	[PMID: 12951082]
CHO-K1	EC₅₀	0.61 nM Compound: 7	Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	[PMID: 12951082]
CHO-K1	EC₅₀	0.013 μM Compound: KRP-101	Transactivation of human PPARalpha expressed in CHO-K1 cells Transactivation of human PPARalpha expressed in CHO-K1 cells	[PMID: 22133631]
CHO-K1	EC₅₀	1.92 μM Compound: KRP-101	Transactivation of human PPARdelta expressed in CHO-K1 cells Transactivation of human PPARdelta expressed in CHO-K1 cells	[PMID: 22133631]
CHO-K1	EC₅₀	2.5 μM Compound: KRP-101	Transactivation of human PPARgamma expressed in CHO-K1 cells Transactivation of human PPARgamma expressed in CHO-K1 cells	[PMID: 22133631]

Chemical Information

No. CAS 311770-26-0
Peso molecular 451.49
Fòrmula C₂₆H₂₆FNO₅
SMILES

FC(C=C1)=CC=C1OC(C=C2)=CC=C2CNC(C3=C(C=CC(C[C@H](CC)C(O)=O)=C3)OC)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Highly sensitive upregulation of apolipoprotein A-IV by peroxisome proliferator-activated receptor alpha (PPARalpha) agonist in human hepatoma cells

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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KRP-101

Ver todos los productos específicos de isoformas PPAR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

KRP-101 Related Classifications

HY-19418 Related Classifications