Lutein
Based on 5 publication(s) in Google Scholar
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.
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- Pureza: 90.0%
- No. CAS: 127-40-2
- Fòrmula: C40H56O2
- Peso molecular:568.87
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Publications Citing Use of MedChemExpress (MCE) Lutein
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Actividad biológica
Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats, severe traumatic brain injury (STBI) model[3]
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Dosage:40, 80 and 160 mg/kg
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Administration:In diet for 5 weeks
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Result:Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.
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Animal Model:Male Swiss mice, chronic Corticosterone (HY-B1618) model of depression[4]
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Dosage:0.1, 1 and 10 mg/kg
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Administration:Oral administration, once or daily for 7 and 21 days
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Result:Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed by Corticosterone (HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 127-40-2
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Appearance Solid
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Peso molecular 568.87
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Fòrmula C40H56O2
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Color Orange to red
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SMILES
CC(/C=C/[C@@H](C(C)=C[C@H](O)C1)C1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(C[C@H](O)C2)C)=C2C
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Synonyms
Xanthophyll
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Structure Classification
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Initial Source
egg's yolk
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (5)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism. [Abstract]2026 May 18. PMID: 42144445 -
Int J Nanomedicine
Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function. [Abstract]2024 Nov 19:19:11973-11996. PMID: 39583319 -
Food Funct
A Capsicum annuum L. seed extract exerts anti-neuroexcitotoxicity in HT22 hippocampal neurons. [Abstract]2024 Feb 19;15(4):2144-2153. PMID: 38305768 -
Int J Mol Sci
Characterization of Inhibitory Capability on Hyperpolarization-Activated Cation Current Caused by Lutein (β,ε-Carotene-3,3'-Diol), a Dietary Xanthophyll Carotenoid. [Abstract]2022 Jun 28;23(13):7186. PMID: 35806190
Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186. [Abstract]
Lutein (3 μM) progressively lessened the amplitude of Ih in pituitary GH3 cells evoked in response to such 2-sec long step hyperpolarization from -40 to -120 mV.
Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186. [Abstract]
Lutein (0.1-100 μM) concentration-dependently inhibited the amplitude of hyperpolarization-activated cation current (Ih) in pituitary GH3 cells.
Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186. [Abstract]
Lutein (1-3 μM) increased the τact value of Ih in pituitary GH3 cells evoked by long-lasting membrane hyperpolarization.
Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186. [Abstract]
Modifications of Lutein (3 μM) on the quasi-steady-state activation curve of hyperpolarization-activated cation current (Ih) seen in GH3 cells.
Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186. [Abstract]
The application of Lutein (1–3 μM) resulted in a conceivable depression of the sag potential evoked in response to a hyperpolarizing current stimulus in GH3 cells.
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Aesthet Surg J
Oral Administration of Lutein Improves Fat Graft Survival by Alleviating Oxidative Stress in Mice. [Abstract]2024 Nov 15;44(12):NP906-NP921. PMID: 39178377
Solvente y solubilidad
DMSO : 25 mg/mL (43.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Buscemi S, et al. The Effect of Lutein on Eye and Extra-Eye Health.Nutrients. 2018 Sep 18;10(9). pii: E1321. [Content Brief]
[2]. Kim SR, et al. Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin. Exp Eye Res. 2006 May;82(5):828-39. [Content Brief]
[3]. Tan D, et al. Lutein protects against severe traumatic brain injury through anti‑inflammation and antioxidative effects via ICAM‑1/Nrf‑2. Mol Med Rep. 2017 Oct;16(4):4235-4240. [Content Brief]
[4]. Zeni ALB, et al. Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities. Pharmacol Biochem Behav. 2019 Apr;179:63-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7579 mL | 8.7894 mL | 17.5787 mL | 43.9468 mL |
| 5 mM | 0.3516 mL | 1.7579 mL | 3.5157 mL | 8.7894 mL | |
| 10 mM | 0.1758 mL | 0.8789 mL | 1.7579 mL | 4.3947 mL | |
| 15 mM | 0.1172 mL | 0.5860 mL | 1.1719 mL | 2.9298 mL | |
| 20 mM | 0.0879 mL | 0.4395 mL | 0.8789 mL | 2.1973 mL | |
| 25 mM | 0.0703 mL | 0.3516 mL | 0.7031 mL | 1.7579 mL | |
| 30 mM | 0.0586 mL | 0.2930 mL | 0.5860 mL | 1.4649 mL | |
| 40 mM | 0.0439 mL | 0.2197 mL | 0.4395 mL | 1.0987 mL |
Lutein Related Classifications
HY-N6947 Related Classifications
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