LW106
LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma.
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- No. CAS: 2116519-76-5
- Fòrmula: C11H11N5O2
- Peso molecular:245.24
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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IDO1 1.57 μM (IC50) |
LW106 (12.5-200 μM) does not affect proliferation of three types of tumor cells (HeLa, Lewis, B16F10 cells) with different expression levels of IDO1[1].
LW106 restores the function of CD8+ T cells by blocking the activity of IDO1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lewis and B16F10 tumors model established in 57BL6 mice, athymic nude mice or Ido1-/- mice[1]
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Dosage:20, 40 and 80 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 18 days
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Result:Dose-dependently inhibited tumor growth of Lewis lung cancer or B16F10 melanoma. Reconstructed the tumor immune microenvironment, enhanced anti-tumor immunity, and inhibited stromal cells and cancer stem cells. Inhibited tumor proliferation, promoted apoptosis, and reduced the matrix barrier.
Inhibited the self-renewal ability of cancer stem cells.
Chemical Information
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No. CAS 2116519-76-5
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Peso molecular 245.24
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Fòrmula C11H11N5O2
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SMILES
O/N=C(N1CC2=C(C1)C=CC=C2)/C3=NON=C3N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LW106 Related Classifications
HY-134920 Related Classifications
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