LY2812223
Based on 1 Customer Validation
LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.0%
- No. CAS: 1311385-20-2
- Fòrmula: C10H12N4O4S
- Peso molecular:284.29
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Almacenamiento:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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mGluR2 144 nM (Ki) |
mGluR3 156 nM (Ki) |
Chemical Information
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No. CAS 1311385-20-2
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Appearance Solid
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Peso molecular 284.29
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Fòrmula C10H12N4O4S
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Color White to off-white
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SMILES
[H][C@]1(C(O)=O)[C@]([C@]1([H])[C@](N)(C(O)=O)C2)([H])[C@@H]2SC3=NN=CN3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
H2O : 50 mg/mL (175.88 mM; Need ultrasonic)
DMSO : 28.75 mg/mL (101.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 140 mg/mL (492.45 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.5175 mL | 17.5877 mL | 35.1753 mL | 87.9384 mL |
| 5 mM | 0.7035 mL | 3.5175 mL | 7.0351 mL | 17.5877 mL | |
| 10 mM | 0.3518 mL | 1.7588 mL | 3.5175 mL | 8.7938 mL | |
| 15 mM | 0.2345 mL | 1.1725 mL | 2.3450 mL | 5.8626 mL | |
| 20 mM | 0.1759 mL | 0.8794 mL | 1.7588 mL | 4.3969 mL | |
| 25 mM | 0.1407 mL | 0.7035 mL | 1.4070 mL | 3.5175 mL | |
| 30 mM | 0.1173 mL | 0.5863 mL | 1.1725 mL | 2.9313 mL | |
| 40 mM | 0.0879 mL | 0.4397 mL | 0.8794 mL | 2.1985 mL | |
| 50 mM | 0.0704 mL | 0.3518 mL | 0.7035 mL | 1.7588 mL | |
| 60 mM | 0.0586 mL | 0.2931 mL | 0.5863 mL | 1.4656 mL | |
| 80 mM | 0.0440 mL | 0.2198 mL | 0.4397 mL | 1.0992 mL | |
| 100 mM | 0.0352 mL | 0.1759 mL | 0.3518 mL | 0.8794 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
LY2812223 Related Classifications
HY-18760 Related Classifications
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