Mardepodect precursor
Mardepodect precursor is the precursor of Mardepodect (HY-50098). Mardepodect precursor. Mardepodect is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs.
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- No. CAS: 871507-11-8
- Fòrmula: C24H18N4O
- Peso molecular:378.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
PDE10A 0.37 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.423 nM
Compound: 3
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Inhibition of rat recombinant PDE10A transfected in Sf9 cells
Inhibition of rat recombinant PDE10A transfected in Sf9 cells
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[PMID: 19630403] |
Chemical Information
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No. CAS 871507-11-8
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Peso molecular 378.43
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Fòrmula C24H18N4O
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SMILES
C1(C2=CNN=C2C3=CC=C(OCC4=NC5=C(C=C4)C=CC=C5)C=C3)=CC=NC=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem, 2009, 52(16), 5188-5196. [Content Brief]
[2]. Grauer SM, et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther, 2009, 331(2), 574-590. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mardepodect precursor Related Classifications
HY-169773 Related Classifications
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