country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-A0269S

Copy Link Print Information

Mecillinam-d₁₂

Name: Mecillinam-d12
Brand: MedChemExpress
SKU: HY-A0269S
Availability: PreOrder

(Synonyms: Amdinocillin-d₁₂; FL 1060-d₁₂)

Mecillinam-d₁₂ (Amdinocillin-d₁₂) is the d₁₂-labeled Mecillinam hydrochloride (HY-A0269A). Mecillinam hydrochloride is a β-lactam Antibiotic. Mecillinam hydrochloride inhibits PBP2. Mecillinam hydrochloride exhibits activity against Gram-negative Enterobacteriaceae, and NDM-/OXA-producing E. coli and K. pneumoniae, and can eradicate catheter/bladder mucosa biofilms and clear planktonic bacteria in urine. Mecillinam hydrochloride acts synergistically with β-lactams and Avibactam (HY-14879), enhancing the activity of β-lactams against E. coli in vitro/in vivo. Mecillinam hydrochloride can be used in research on catheter-associated bacteriuria, chlamydial infection and peritonitis/sepsis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₅H₁₁D₁₂N₃O₃S
Peso molecular:337.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Mecillinam-d₁₂ Chemical Structure

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Aplicación
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[6]

β-lactam

Ver todos los productos específicos de isoformas Antibiotic :

Aplicación

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 32887-01-7
Peso molecular 337.50
Fòrmula C₁₅H₁₁D₁₂N₃O₃S
SMILES

OC([C@@H]1N2[C@@](SC1(C)C)([H])[C@@H](C2=O)/N=C/N3C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C3([2H])[2H])=O
Synonyms

Amdinocillin-d₁₂; FL 1060-d₁₂
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Olson ME, et al. Amdinocillin treatment of catheter-associated bacteriuria in rabbits. The Journal of infectious diseases. 1989 Jun;159(6):1065-72. [Content Brief]

[2]. Neu HC, et al. Mecillinam, a novel penicillanic acid derivative with unusual activity against gram-negative bacteria. Antimicrobial agents and chemotherapy. 1976 May;9(5):793-9. [Content Brief]

[3]. Cox JV, et al. Penicillin-binding proteins regulate multiple steps in the polarized cell division process of Chlamydia. Scientific reports. 2020 Jul 28;10(1):12588.

[4]. van der Voet GB, et al. The antibacterial activity of combinations of mecillinam and ampicillin in vitro and in normal and granulopenic mice. Scandinavian journal of infectious diseases. 1983;15(1):91-6.

[5]. List KK, et al. Synergy between Mecillinam and Ceftazidime/Avibactam or Avibactam against Multi-Drug-Resistant Carbapenemase-Producing Escherichia coli and Klebsiella pneumoniae. Antibiotics (Basel). 2022 Sep 20;11(10):1280. [Content Brief]

[6]. Thulin E, et al. Amdinocillin (Mecillinam) resistance mutations in clinical isolates and laboratory-selected mutants of Escherichia coli. Antimicrob Agents Chemother. 2015 Mar;59(3):1718-27.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Aplicación
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Mecillinam-d₁₂

Ver todos los productos específicos de isoformas Antibiotic