Mepazine
Based on 2 publication(s) in Google Scholar
Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis.
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- Pureza: 99.71%
- No. CAS: 60-89-9
- Fòrmula: C19H22N2S
- Peso molecular:310.46
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Drug-Induced Liver Injury (DILI) Compound Library
HY-L076
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Anti-Blood Cancer Compound Library
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Protease Inhibitor Library
HY-L147
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
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Bioactive Compound Library Max
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Publications Citing Use of MedChemExpress (MCE) Mepazine
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Actividad biológica
MALT1[1]
Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4)
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Concentration:5, 10, and 20 μM
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Incubation Time:4 days
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Result:Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model[1]
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Dosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg.
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Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application
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Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
Chemical Information
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No. CAS 60-89-9
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Appearance Oil
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Peso molecular 310.46
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Fòrmula C19H22N2S
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Color Light yellow to light brown
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SMILES
CN1CC(CCC1)CN2C3=C(SC4=CC=CC=C24)C=CC=C3
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Synonyms
Pecazine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Blood
2022 Sep 29;140(13):1549-1564. PMID: 35895897 -
Int J Mol Sci
Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. [Abstract]2023 Apr 17;24(8):7402. PMID: 37108564
Solvente y solubilidad
DMSO : 100 mg/mL (322.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (16.11 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (702 KB)
- English - EN (702 KB)
- Français - FR (702 KB)
- Deutsch - DE (702 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2210 mL | 16.1051 mL | 32.2103 mL | 80.5257 mL |
| 5 mM | 0.6442 mL | 3.2210 mL | 6.4421 mL | 16.1051 mL | |
| 10 mM | 0.3221 mL | 1.6105 mL | 3.2210 mL | 8.0526 mL | |
| 15 mM | 0.2147 mL | 1.0737 mL | 2.1474 mL | 5.3684 mL | |
| 20 mM | 0.1611 mL | 0.8053 mL | 1.6105 mL | 4.0263 mL | |
| 25 mM | 0.1288 mL | 0.6442 mL | 1.2884 mL | 3.2210 mL | |
| 30 mM | 0.1074 mL | 0.5368 mL | 1.0737 mL | 2.6842 mL | |
| 40 mM | 0.0805 mL | 0.4026 mL | 0.8053 mL | 2.0131 mL | |
| 50 mM | 0.0644 mL | 0.3221 mL | 0.6442 mL | 1.6105 mL | |
| 60 mM | 0.0537 mL | 0.2684 mL | 0.5368 mL | 1.3421 mL | |
| 80 mM | 0.0403 mL | 0.2013 mL | 0.4026 mL | 1.0066 mL | |
| 100 mM | 0.0322 mL | 0.1611 mL | 0.3221 mL | 0.8053 mL |
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